Evidence for human microRNA-offset RNAs in small RNA sequencing data
Evidence for human microRNA-offset RNAs in small RNA sequencing data
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DOI：
10.1093/bioinformatics/btp419
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发表时间：
2009-09-15
期刊：
影响因子：
5.8
通讯作者：
Stadler, Peter F.
中科院分区：
文献类型：
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作者：
Langenberger, David;Bermudez-Santana, Clara;Stadler, Peter F.
最近在基底脊椎动物中检测到MicroRNA offset-RNA（MORNA）是高度丰富的小RNA类。使用简短的读取测序数据，我们在这里表明MORNA也是由人类MicroRNA前体产生的，尽管表达水平很低。 MORNA的表达水平与相关microRNA的表达水平无关。令人惊讶的是，也表明MORNA的microRNA前体通常在进化上是旧的，其中一半以上是在早期双层植物中存在的MicroRNA家族，而MORNA的证据仅是因为最近起源的MicroRNA家族的相对小部分。
MicroRNA-offset-RNAs (moRNAs) were recently detected as highly abundant class of small RNAs in a basal chordate. Using short read sequencing data, we show here that moRNAs are also produced from human microRNA precursors, albeit at quite low expression levels. The expression levels of moRNAs are unrelated to those of the associated microRNAs. Surprisingly, microRNA precursors that also show moRNAs are typically evolutionarily old, comprising more than half of the microRNA families that were present in early Bilateria, while evidence for moRNAs was found only for a relative small fraction of microRNA families of recent origin.