Lichen Planopilaris: Update on Diagnosis and Treatment
Lichen Planopilaris: Update on Diagnosis and Treatment
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DOI：
10.1016/j.sder.2008.12.006
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发表时间：
2009-03-01
影响因子：
--
通讯作者：
Reygagne, Pascal
中科院分区：
文献类型：
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作者：
Assouly, Philippe;Reygagne, Pascal
扁平苔藓 (LPP) 是扁平苔藓的一种滤泡形式，是一种罕见的炎症淋巴细胞介导的疾病。尽管病理生理学尚不清楚，但自身免疫病因已被普遍接受。女性比男性更容易受到影响，典型的发病年龄在 40 至 60 岁之间。 LLP 是一种原发性瘢痕性脱发，其早期诊断得到临床和组织病理学结果的支持。在毛囊周围紫红色红斑和尖锐角化栓扩大区域的边缘内，组织学可显示毛囊周围苔藓样炎症。 LPP 可细分为 3 种变体：经典 LPP、额叶纤维化性脱发 (FFA) 和 Lassueur Graham-Little Piccardi 综合征。除 FFA 外，头皮的无毛斑可以是独特的，也可以是多个出现的，并且可以呈现网状图案或大面积的疤痕。这种情况可能会对受影响的患者产生重大的心理后果。治疗管理通常相当具有挑战性，因为局部或全身治疗后复发很常见。需要对发病机制进行进一步研究，并且需要对治疗结果进行随机对照试验并对结果进行科学评估，以了解所提出的治疗方法。 Semin Cutan Med Surg 28:3-10 (C) 2009 Elsevier Inc. 保留所有权利。
Lichen planopilaris (LPP), a follicular form of lichen planus, is a rare inflammatory lymphocyte mediated disorder. Although the physiopathology is unclear, an autoimmune etiology is generally accepted. Women are affected more than men, and the typical age of onset is between 40 and 60 years. LLP is a primary cicatricial alopecia whose diagnosis is supported in the early stage by both clinical and histopathological findings. Within the margins of the expanding areas of perifollicular violaceous erythema and acuminate keratotic plugs, the histology can show the lichenoid perifollicular inflammation. LPP can be subdivided into 3 variants: classic LPP, frontal fibrosing alopecia (FFA), and Lassueur Graham-Little Piccardi syndrome. With the exception of FFA, the hairless patches of the scalp can be unique or can occur in multiples and can present with a reticular pattern or as large areas of scarring. This condition can have major psychological consequences for the affected patients. The therapeutic management often is quite challenging, as relapses are common after local or systemic treatments. Further research is needed on the pathogenesis, and randomized controlled trials of treatment with scientific evaluation of the results are necessary to appreciate the proposed treatment. Semin Cutan Med Surg 28:3-10 (C) 2009 Elsevier Inc. All rights reserved.