Rearing environment and hypothalamic-pituitary-adrenal regulation in young rhesus monkeys (Macaca mulatta)
Rearing environment and hypothalamic-pituitary-adrenal regulation in young rhesus monkeys (Macaca mulatta)
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DOI：
10.1002/dev.20067
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发表时间：
2005-05-01
影响因子：
2.2
通讯作者：
Maninger, N
中科院分区：
文献类型：
--
作者：
Capitanio, JP;Mendoza, SP;Maninger, N
哺乳动物的早期社会环境对其行为和生理有重要的调节作用，尤其是对下丘脑-垂体-肾上腺（HPA）系统的调节。本研究旨在验证假设，社会环境的各个方面对HPA调节有重要影响。778只3- 4个月大的恒河猴作为标准化的24小时生物行为评估计划的一部分进行了研究，其中包括采血测定血浆皮质醇浓度。结果表明，托儿所饲养的结果在降低皮质醇的HPA系统的设定点，和，托儿所饲养（NR）的动物，更多的同龄人在婴儿期接触与较高的设定点。在此期间，年龄和性别差异很明显，但幅度很小。这些数据表明了社会环境对非人类灵长类动物生理学的重要调节作用，并建议谨慎假设个体皮质醇水平之间的差异仅反映了对事件“压力”的感知差异。© 2005 Wiley-Liss公司。
A mammal's early social environment has important regulatory effects on its behavior and physiology, and this is especially true for regulation of the hypothalamic-pituitary-adrenal (HPA) system. The present study was designed to test hypotheses that various aspects of the social environment are important influences on HPA regulation. Seven hundred seventy eight, 3- to 4-month-old rhesus monkeys were studied as part of a standardized, 24-hr biobehavioral assessment program, which included blood sampling to determine plasma cortisol concentrations. Results indicate that nursery-rearing results in a reduced cortisol set-point for the HPA system, and, for nursery-reared (NR) animals, more peer exposure during infancy is associated with a higher set-point. Age and sex differences during this period were evident but small in magnitude. These data demonstrate the important regulatory role of the social environment on nonhuman primate physiology and suggest caution in assuming that differences between individuals' cortisol levels reflect only differences in perceptions of the "stressfulness" of events. © 2005 Wiley-Liss, Inc.