Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
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DOI：
10.1016/s0014-5793(97)00755-2
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发表时间：
1997-07-21
期刊：
影响因子：
3.5
通讯作者：
Giacobino, JP
中科院分区：
文献类型：
--
作者：
Boss, O;Samec, S;Giacobino, JP
研究了大鼠棕色脂肪组织（BAT）、心脏和骨骼肌中解偶联蛋白-2（UCP 2）mRNA表达的调控。冷暴露（48 h）使BAT、心脏和比目鱼肌中UCP 2 mRNA的表达分别增加2.4、4.3和2.6倍。禁食（48 h）对BAT和心脏中UCP 2 mRNA的表达均无影响。但在骨骼肌中显著增加，而UCP 2 mRNA在冷暴露中的上调与该蛋白在体温调节产热中的假定解偶联作用一致，骨骼肌中UCP 2对禁食反应的意外上调似乎与其作为参与饮食调节的解偶联蛋白的作用不一致，产热作用(C)1997年欧洲生物化学学会联合会。
The control of uncoupling protein-2 (UCP2) mRNA expression in rat brown adipose tissue (BAT), heart and skeletal muscles was examined, Cold exposure (48 h) increased UCP2 mRNA in BAT, heart and soleus muscle by 2.4-, 4.3- and 2.6-fold, respectively, Fasting (48 h) had no effect on UCP2 mRNA expression neither in BAT nor in heart, but markedly increased it in skeletal muscles, While the upregulation of UCP2 mRNA in response to cold exposure is in line with a putative uncoupling role for this protein in thermoregulatory thermogenesis, the unexpected upregulation of UCP2 in skeletal muscles in response to fasting seems inconsistent with its role as an uncoupling protein involved in dietary regulation of thermogenesis. (C) 1997 Federation of European Biochemical Societies.