Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years.
Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years.
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DOI：
10.1101/pdb.top069906
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发表时间：
2015-10-01
影响因子：
--
通讯作者：
Kemp, Christopher J
中科院分区：
文献类型：
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作者：
Kemp, Christopher J
通过对动物进行化学致癌研究，确定工作场所、饮食和环境中的致癌物，直接有助于减轻人类的癌症负担。通过改变生活方式、政府监管或改变工业惯例来减少接触这些致癌物，降低了接触人群的癌症发病率。除了为癌症与化学和辐射暴露之间的关系提供第一个实验证据外，环境诱发癌症的动物模型已经并将继续为癌症的原因、机制和概念框架提供重要的见解。最近，将化学致癌物与基因工程小鼠模型相结合已成为研究基因型和环境之间复杂相互作用的宝贵方法，这些相互作用有助于癌症的发展。在未来，环境诱导癌症的动物模型可能会为癌症的表观遗传学基础、癌症易感性的遗传修饰剂、癌症、炎症和癌症的系统生物学以及癌症预防等领域提供见解。
The identification of carcinogens in the workplace, diet, and environment through chemical carcinogenesis studies in animals has directly contributed to a reduction of cancer burden in the human population. Reduced exposure to these carcinogens through lifestyle changes, government regulation, or change in industry practices has reduced cancer incidence in exposed populations. In addition to providing the first experimental evidence for cancer's relationship to chemical and radiation exposure, animal models of environmentally induced cancer have and will continue to provide important insight into the causes, mechanisms, and conceptual frameworks of cancer. More recently, combining chemical carcinogens with genetically engineered mouse models has emerged as an invaluable approach to study the complex interaction between genotype and environment that contributes to cancer development. In the future, animal models of environmentally induced cancer are likely to provide insight into areas such as the epigenetic basis of cancer, genetic modifiers of cancer susceptibility, the systems biology of cancer, inflammation and cancer, and cancer prevention.