Vascular cognitive impairment and dementia: An early career researcher perspective.
Vascular cognitive impairment and dementia: An early career researcher perspective.
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血管认知障碍和痴呆：早期职业研究员的观点。
DOI：
10.1002/dad2.12310
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发表时间：
2022
影响因子：
5.3
通讯作者：
Price, Brittani R
中科院分区：
文献类型：
--
作者：
Silva, Narlon C Boa Sorte;Bracko, Oliver;Nelson, Amy R;de Oliveira, Fabricio Ferreira;Robison, Lisa S;Shaaban, C Elizabeth;Hainsworth, Atticus H;Price, Brittani R
血管对认知损害和痴呆的贡献(VCID)领域正在迅速发展。VCID的研究包括旨在了解、预防和治疗人类大脑中血管疾病负担的有害影响的主题。在这篇透视文章中，该领域的早期职业研究人员(ECR)提供了VCID的概述，讨论了过去和现在的努力，并强调了未来研究的优先事项。随着该领域的进展，我们强调以下关键点：(A)整合现有的神经成像和流体生物标记物，并确定其用于药理学和非药理学干预；(B)开发新的生物标记物和新的非临床模型，更好地概括血管病理；(C)扩大对新兴生物标记物和成像技术的获取；(D)验证先前在不同人群，包括认知障碍风险较高的人群(如黑人、西班牙裔和土著人群)进行的研究结果；以及(E)在具有良好特征的血管病理的不同人群中进行随机对照试验，重点关注具有临床意义的结果。
The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the detrimental effects of vascular disease burden in the human brain. In this perspective piece, early career researchers (ECRs) in the field provide an overview of VCID, discuss past and present efforts, and highlight priorities for future research. We emphasize the following critical points as the field progresses: (a) consolidate existing neuroimaging and fluid biomarkers, and establish their utility for pharmacological and non‐pharmacological interventions; (b) develop new biomarkers, and new non‐clinical models that better recapitulate vascular pathologies; (c) amplify access to emerging biomarker and imaging techniques; (d) validate findings from previous investigations in diverse populations, including those at higher risk of cognitive impairment (e.g., Black, Hispanic, and Indigenous populations); and (e) conduct randomized controlled trials within diverse populations with well‐characterized vascular pathologies emphasizing clinically meaningful outcomes.