Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice
Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice
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DOI：
10.1002/ptr.964
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发表时间：
2001-09-01
影响因子：
7.2
通讯作者：
Ishiguro, K
中科院分区：
文献类型：
--
作者：
Oku, H;Ishiguro, K
我们研究了凤仙花（Impatiens balsamina L.）花瓣35%乙醇提取物（IB）及其主要活性化合物对慢性和严重瘙痒和皮炎发展的影响，使用NC小鼠（特应性皮炎模型）。100 mg/kg的IB在测量前1小时或测量前24小时给药，可显著抑制已建立皮炎的NC小鼠的严重抓痕行为。从IB中分离的山奈酚3-芦丁苷和2-羟基-1,4-萘醌（lawsone） 10杯/kg剂量也能抑制患有皮炎的NC小鼠的抓伤行为。当没有症状的4周龄NC小鼠口服100 mg/kg/天IB至13周龄时，还注意到在皮炎发展过程中对抓伤行为的保护。IB对预防和治疗特应性皮炎有较好的疗效。版权所有John Wiley & Sons， Ltd。
We examined the effects of a 35% ethanol extract (IB) from the petals of Impatiens balsamina L. and the principal active compounds from IB on chronic and serious pruritus and the development of dermatitis using NC mice, a model of atopic dermatitis. IB at 100 mg/kg significantly inhibited serious scratching behaviour in the NC mouse with established dermatitis when administered i.v. 1 h before, or p.o. 24 h before the measurement. A 10 mug/kg dose of kaempferol 3-rutinoside and 2-hydroxy-1,4-naphthoquinone (lawsone) isolated from IB also inhibited scratching behaviour in the NC mouse with established dermatitis. When 4-week-old NC mice with no symptoms were administered orally 100 mg/kg/day of IB until 13 weeks of age, protection was also noted against scratching behaviour during the development of dermatitis. IB was effective for the prevention and treatment of atopic dermatitis. Copyright (C) 2001 John Wiley & Sons, Ltd.