Social inequalities in biomarkers of cardiovascular risk in adolescence
Social inequalities in biomarkers of cardiovascular risk in adolescence
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DOI：
10.1097/01.psy.0000149254.36133.1a
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Adler, NE
中科院分区：
文献类型：
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作者：
Goodman, E;McEwen, BS;Adler, NE
目的：心血管疾病，开始于生命早期，但往往是不明显的，直到成年，是国家的主要死因。心血管疾病方面的社会不平等现象普遍存在，但人们对其产生的过程知之甚少。本研究的目的是探讨青少年的社会经济地位、一系列反映心血管风险的生物标志物和累积生理风险评分之间的关系。研究方法：在中西部郊区公立学区的非西班牙裔黑人和白色高中生（N = 758）进行了体格检查，测量身高，体重和腰围，并在早晨空腹抽取血液样本，以评估皮质醇，胰岛素，葡萄糖，糖化血红蛋白，纤维蛋白原，低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇和甘油三酯。根据这些生理指标和腰围建立累积风险评分。在另一项调查中，从一位家长那里获得了有关家长教育和家庭收入的信息。广义估计方程模型用于评估父母教育与风险的关联，以及调整年龄、性别和种族的累积风险评分。结果如下：父母受教育程度低与高胰岛素、高葡萄糖、胰岛素抵抗、高LDL胆固醇、低HDL胆固醇、腰围和体重指数相关（p
Objective: Cardiovascular disease, which begins early in life but often is not manifest until adulthood, is the nation's leading cause of mortality. Social inequalities in cardiovascular disease are pervasive, yet the process by which they accrue is poorly understood. The objective of this study was to explore the associations between socioeconomic status, a range of biomarkers reflective of cardiovascular risks, and a cumulative physiological risk score among adolescents. Methods: Non-Hispanic black and white high school students (N = 758) in a suburban Midwestern public school district had a physical examination to measure height, weight, and waist circumference and a fasting morning blood sample drawn to assess cortisol, insulin, glucose, glycosylated hemoglobin, fibrinogen, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglycerides. A cumulative risk score was created from these physiological measures and waist circumference. Information on parent education and household income was obtained from a parent in a separate survey. Generalized estimating equation models were used to assess the association of parent education to the risks and the cumulative risk score adjusting for age, gender, and race. Results: Lower parent education was associated with higher insulin, higher glucose, greater insulin resistance, higher LDL cholesterol, lower HDL cholesterol, higher waist circumference, and higher body mass index (p