Structural insights into the regulatory mechanism Of IP3 receptor
Structural insights into the regulatory mechanism Of IP3 receptor
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DOI：
10.1016/j.bbamcr.2004.09.016
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发表时间：
2004-12-06
影响因子：
5.1
通讯作者：
Ikura, M
中科院分区：
文献类型：
--
作者：
Bosanac, I;Michikawa, T;Ikura, M
肌醇1,4,5-三磷酸受体（IP3R）是细胞内Ca2+释放通道，其打开需要结合两个细胞内信使IP3和Ca2+。IP3R功能的调控也被证明涉及多种细胞蛋白。最近的生化和结构分析加深了我们对ip3如何操作Ca2+通道功能的理解。具体来说，ip3结合区的原子分辨率结构为受体与天然配体的相互作用提供了良好的结构基础。电子显微镜研究也揭示了四聚体受体的整体形状。本文旨在对IP3R的结构与功能关系的研究现状进行综述。(C) 2004 Elsevier B.V.版权所有
Inositol 1,4,5-trisphosphate receptors (IP3R) are intracellular Ca2+ release channels whose opening requires binding of two intracellular messengers IP3 and Ca2+. The regulation of IP3R function has also been shown to involve a variety of cellular proteins. Recent biochemical and structural analyses have deepened our understanding of how the IP3-operated Ca2+ channel functions. Specifically, the atomic resolution structure of the IP3-binding region has provided a sound structural basis for the receptor interaction with the natural ligand. Electron microscopic studies have also shed light on the overall shape of the tetrameric receptor. This review aims to provide comprehensive overview of the current information available on the structure and function relationship of IP3R. (C) 2004 Elsevier B.V. All rights reserved.