Obesity and Melanoma: Exploring Molecular Links
Obesity and Melanoma: Exploring Molecular Links
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DOI：
10.1002/jcb.24549
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发表时间：
2013-09-01
影响因子：
4
通讯作者：
Zhang, Xu Dong
中科院分区：
文献类型：
--
作者：
Chen, Jiezhong;Chi, Mengna;Zhang, Xu Dong
由于肥胖在世界范围内的发病率迅速上升和后果严重，它现在是一个主要的健康问题。在许多与肥胖相关的疾病中，包括黑色素瘤在内的一些癌症。遗传缺陷和环境危险因素都与黑色素瘤的癌变有关。多种信号通路如PI3K/Akt和MAPK通路的激活是黑色素瘤发生的必要条件。BRAF突变激活MAPK通路在黑色素瘤中很常见，但它本身并不足以引起黑素细胞的恶性转化。肥胖可导致许多信号通路的激活，包括PI3K/Akt、MAPK和STAT3。这些通路的激活可能与遗传缺陷有协同作用，从而增加黑色素瘤的发病率。j .细胞。生物化学学报，2013,29(4):555 - 561。(c) 2013 Wiley Periodicals, Inc.；
Obesity is now a major health problem due to its rapidly increasing incidence worldwide and severe consequences. Among many conditions associated with obesity are some cancers including melanoma. Both genetic defects and environmental risk factors are involved in the carcinogenesis of melanoma. Activation of multiple signal pathways such as the PI3K/Akt and MAPK pathways are necessary for the initiation of melanoma. Activation of the MAPK pathway as a result of activating mutations in BRAF is commonly seen in melanoma though it alone is not sufficient to cause malignant transformation of melanocytes. Obesity can result in the activation of many signal pathways including PI3K/Akt, MAPK, and STAT3. The activation of these pathways may have a synergistic effect with the genetic defects thereby increasing the incidence of melanoma. J. Cell. Biochem. 114: 1955-1961, 2013. (c) 2013 Wiley Periodicals, Inc.