ErbB2 is required for cardiomyocyte proliferation in murine neonatal hearts.
ErbB2 is required for cardiomyocyte proliferation in murine neonatal hearts.
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DOI：
10.1016/j.gene.2016.07.006
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发表时间：
2016-11-05
期刊：
影响因子：
3.5
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Ma H;Yin C;Zhang Y;Qian L;Liu J
哺乳动物心脏在出生后不久即丧失其增殖能力，这一点早已被认识到，然而，这种出生后心脏增殖能力丧失的分子基础在很大程度上是未知的。在这项研究中，我们发现，心脏ErbB2，表皮生长因子受体家族的成员，在新生儿阶段表现出快速和显着的表达下降。我们进一步证明，在狭窄的新生儿增殖时间窗期间，心室肌中ErbB2的条件性消融导致负细胞周期调节因子的上调和心肌细胞增殖的显著减少。总之，我们的数据揭示了ErbB2的表达水平与新生儿心肌细胞增殖之间的正相关性，并表明心脏ErbB2表达的减少可能有助于出生后心肌细胞增殖能力的丧失。
It has been long recognized that the mammalian heart loses its proliferative capacity soon after birth, yet, the molecular basis of this loss of cardiac proliferation postnatally is largely unknown. In this study, we found that cardiac ErbB2, a member of the epidermal growth factor receptor family, exhibits a rapid and dramatic decline in expression at the neonatal stage. We further demonstrate that conditional ablation of ErbB2 in the ventricular myocardium results in upregulation of negative cell cycle regulators and a significant reduction in cardiomyocyte proliferation during the narrow neonatal proliferative time window. Together, our data reveal a positive correlation between the expression levels of ErbB2 with neonatal cardiomyocyte proliferation and suggest that reduction in cardiac ErbB2 expression may contribute to the loss of postnatal cardiomyocyte proliferative capacity.