Technical Note: Characterization of custom 3D printed multiodality imaging phantoms
Technical Note: Characterization of custom 3D printed multiodality imaging phantoms
复制标题
DOI：
10.1118/1.4930803
复制
发表时间：
2015-10-01
期刊：
影响因子：
3.8
通讯作者：
Levin, Craig S.
中科院分区：
文献类型：
--
作者：
Bieniosek, Matthew F.;Lee, Brian J.;Levin, Craig S.
目的：成像模体是研究人员和技术人员的重要工具，但它们可能很昂贵，而且很难定制。三维(3D)打印是一种广泛使用的快速原型技术，它使得能够制造具有3D计算机生成的几何形状的对象。它是快速生产定制、低成本、多模式、可重复使用的成像模体的理想选择。这项工作通过比较3D打印体模和商业“微型豪华”体模的CT和PET扫描来验证3D打印体模的使用。本报告还提供了定制的3D打印PET/MRI体模和定制的具有亚毫米特征的高分辨率成像体模的结果。方法：采集直径分别为1.2、1.6、2.4、3.2、4.0和4 8 mm热棒的3D打印体模和商用Micro Deluxe(Data Spectrum Corporation，USA)体模的CT和PET扫描结果。比较了测量的PET和CT棒的尺寸、活度和衰减系数。对具有热棒和冷棒的定制3D打印体模进行了PET/MRI扫描，并使用单独的3D打印归一化体模进行了光子衰减和归一化测量。对定制的具有亚毫米特征的两级高分辨率3D打印体模进行了X射线透射式扫描。结果：商业和3D打印的微型豪华体模具有很好的一致性，CT测量的棒直径相差不到3%，PET测量的棒直径相差不到5%，与西门子Inveon(西门子医疗，德国)PET扫描10分钟，333kBq/ml(9mU Ci/ml)的平均棒活动最大相差6.2%。在所有情况下，这些差异都在我们设置的测量不确定度范围内。PET/MRI扫描成功地在PET和MRI设备上识别了3D打印的热棒和冷棒。3D打印高分辨率体模的X射线投影图像识别出了宽度为350 PM的小特征。结论：这项工作表明，3D打印体模在功能上可以等同于商用体模。它们是快速分发和制造低成本定制幻影的可行选择。(C)2015年美国医学物理学家协会。
Purpose: Imaging phantoms are important tools for researchers and technicians, but they can be costly and difficult to customize. Three dimensional (3D) printing is a widely available rapid prototyping technique that enables the fabrication of objects with 3D computer generated geometries. It is ideal for quickly producing customized, low cost, multimodal, reusable imaging phantoms. This work validates the use of 3D printed phantoms by comparing CT and PET scans of a 3D printed phantom and a commercial "Micro Deluxe" phantom. This report also presents results from a customized 3D printed PET/MRI phantom, and a customized high resolution imaging phantom with sub-mm features.Methods: CT and PET scans of a 3D printed phantom and a commercial Micro Deluxe (Data Spectrum Corporation, USA) phantom with 1.2, 1.6, 2.4, 3.2, 4.0, and 4 8 mm diameter hot rods were acquired. The measured PET and CT rod sizes, activities, and attenuation coefficients were compared. A PET/MRI scan of a custom 3D printed phantom with hot and cold rods was performed, with photon attenuation and normalization measurements performed with a separate 3D printed normalization phantom. X-ray transmission scans of a customized two level high resolution 3D printed phantom with sub-mm features were also performed.Results: Results show very good agreement between commercial and 3D printed micro deluxe phantoms with less than 3% difference in CT measured rod diameter, less than 5% difference in PET measured rod diameter, and a maximum of 6.2% difference in average rod activity from a 10 min, 333 kBq/ml (9 mu Ci/ml) Siemens Inveon (Siemens Healthcare, Germany) PET scan. In all cases, these differences were within the measurement uncertainties of our setups. PET/MRI scans successfully identified 3D printed hot and cold rods on PET and MRI modalities. X-ray projection images of a 3D printed high resolution phantom identified features as small as 350 pm wide.Conclusions: This work shows that 3D printed phantoms can be functionally equivalent to commercially available phantoms. They are a viable option for quickly distributing and fabricating low cost, customized phantoms. (C) 2015 American Association of Physicists in Medicine.