Acquisition of classically conditioned-related activity in the hippocampus is affected by lesions of the cerebellar interpositus nucleus.
Acquisition of classically conditioned-related activity in the hippocampus is affected by lesions of the cerebellar interpositus nucleus.
复制标题
海马中经典条件相关活动的获得受到小脑间核损伤的影响。
DOI：
10.1037//0735-7044.104.5.681
复制
发表时间：
1990
影响因子：
1.9
通讯作者：
Steinmetz,JE
中科院分区：
文献类型：
--
作者：
Sears,LL;Steinmetz,JE
首先给予家兔左侧小脑间位核损伤，然后采用经典的瞬膜（NM）条件反射，采用成对呈现的音调条件刺激（CS）和吹气非条件刺激（UCS）。在训练过程中监测多单位海马活动。在兔前间位病变，收购的学习反应和训练相关的海马活动的显着增加时，防止配对训练给予左侧NM，但不是当训练切换到右侧NM。间位肌前部或周围小脑区域有病变的家兔，其行为反应或海马活动没有表现出缺陷。这些结果表明，收购条件相关的活动在海马依赖于一个完整的小脑间位核。（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
Rabbits were first given left cerebellar interpositus nucleus lesions followed by classical nictitating membrane (NM) conditioning using paired presentations of a tone conditioned stimulus (CS) and an air puff unconditioned stimulus (UCS). Multiple-unit hippocampal activity was monitored over the course of training. In rabbits with anterior interpositus lesions, the acquisition of learned responses and significant increases in training-related hippocampal activity were prevented when paired training was given to the left NM but not when training was switched to the right NM. Rabbits with lesions anterior to the interpositus or in surrounding cerebellar regions failed to show deficits in behavioral responding or hippocampal activity. These results indicate that acquisition of conditioning-related activity in the hippocampus depends on an intact interpositus nucleus of the cerebellum.(PsycINFO Database Record (c) 2016 APA, all rights reserved)