Sugar activation and glycosylation in Plasmodium.
Sugar activation and glycosylation in Plasmodium.
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DOI：
10.1186/s12936-015-0949-z
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发表时间：
2015-10-31
期刊：
影响因子：
3
通讯作者：
Izquierdo L
中科院分区：
文献类型：
--
作者：
Cova M;Rodrigues JA;Smith TK;Izquierdo L
糖缀合物是宿主-病原体相互作用的重要介质，通常在许多原生动物寄生虫的表面非常丰富。然而，在疟原虫物种的特定情况下，以前的工作表明，糖基磷脂酰肌醇锚修饰，并在一个未知的程度上，严重截短的N-糖基化是唯一的糖基化过程中发生的寄生虫。然而，寄生虫基因组的详细分析和最近鉴定的糖核苷酸前体生物合成的恶性疟原虫支持的图片中，几个被忽视的，虽然不是很突出的糖基化可能发生在寄生虫的生命周期。在这项工作中，作者回顾了最近的事态发展，在寄生虫中的糖基化前体的生物合成的表征，侧重于这些前体的可能的命运的轮廓。
Glycoconjugates are important mediators of host-pathogen interactions and are usually very abundant in the surface of many protozoan parasites. However, in the particular case of Plasmodium species, previous works show that glycosylphosphatidylinositol anchor modifications, and to an unknown extent, a severely truncated N-glycosylation are the only glycosylation processes taking place in the parasite. Nevertheless, a detailed analysis of the parasite genome and the recent identification of the sugar nucleotide precursors biosynthesized by Plasmodium falciparum support a picture in which several overlooked, albeit not very prominent glycosylations may be occurring during the parasite life cycle. In this work, the authors review recent developments in the characterization of the biosynthesis of glycosylation precursors in the parasite, focusing on the outline of the possible fates of these precursors.