Neural Network Configuration and Efficiency Underlies Individual Differences in Spatial Orientation Ability
Neural Network Configuration and Efficiency Underlies Individual Differences in Spatial Orientation Ability
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DOI：
10.1162/jocn_a_00491
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发表时间：
2014-02-01
影响因子：
3.2
通讯作者：
Iaria, Giuseppe
中科院分区：
文献类型：
--
作者：
Arnold, Aiden E. G. F.;Protzner, Andrea B.;Iaria, Giuseppe
空间定向是一个复杂的认知过程，需要整合大脑各区域的分布式系统中处理的信息。目前关于空间定向神经基础的模型主要是基于单个脑区的功能作用，对这些脑区之间的相互作用如何与行为相关的理解有限。在这项研究中，我们调查了支持空间定位网络结构和效率的神经网络中的两个可变性来源，并评估了这些拓扑属性的可变性是否与定位精度的个体差异有关。研究显示，准确率较高的受试者在右侧边缘上回、右侧中央前皮质和左侧海马区表现出更大的活动，超过了整个组参与的核心网络。此外，表现优秀的个体在由定位时参与的大脑区域和右侧边缘上回、右侧初级运动皮质和左侧海马区的节点中心水平组成的休息状态网络中，整体效率水平都有所提高。这些结果表明，任务相关网络的结构及其静态效率的个体差异与空间定向能力有关。我们的发现通过提供对功能整合在塑造定向行为中的作用的洞察，推进了定向和导航的系统神经科学模型。
Spatial orientation is a complex cognitive process requiring the integration of information processed in a distributed system of brain regions. Current models on the neural basis of spatial orientation are based primarily on the functional role of single brain regions, with limited understanding of how interaction among these brain regions relates to behavior. In this study, we investigated two sources of variability in the neural networks that support spatial orientationnetwork configuration and efficiencyand assessed whether variability in these topological properties relates to individual differences in orientation accuracy. Participants with higher accuracy were shown to express greater activity in the right supramarginal gyrus, the right precentral cortex, and the left hippocampus, over and above a core network engaged by the whole group. Additionally, high-performing individuals had increased levels of global efficiency within a resting-state network composed of brain regions engaged during orientation and increased levels of node centrality in the right supramarginal gyrus, the right primary motor cortex, and the left hippocampus. These results indicate that individual differences in the configuration of task-related networks and their efficiency measured at rest relate to the ability to spatially orient. Our findings advance systems neuroscience models of orientation and navigation by providing insight into the role of functional integration in shaping orientation behavior.