Enhanced population responses in the basolateral amygdala of kainate-treated, epileptic rats in vitro.
Enhanced population responses in the basolateral amygdala of kainate-treated, epileptic rats in vitro.
复制标题
体外红藻氨酸处理的癫痫大鼠基底外侧杏仁核的群体反应增强。
DOI：
10.1016/s0304-3940(97)13326-2
复制
发表时间：
1997
影响因子：
2.5
通讯作者：
Dudek,FE
中科院分区：
文献类型：
--
作者：
Smith,BN;Dudek,FE
多项证据表明，患有颞叶癫痫的人的杏仁核功能发生了改变，但对于患有慢性癫痫的人或动物的杏仁核神经元相互作用知之甚少。使用水平切片中的细胞外和细胞内记录，我们测试了这样的假设：基底外侧杏仁核（BLA）局部回路的变化永久增强了红藻氨酸治疗的癫痫大鼠的神经元反应性。 BLA 中的群体对顺向刺激的反应显着增强，这至少部分是由于局部抑制的减少。在 GABA 受体拮抗剂存在的情况下，癫痫大鼠的群体反应大约是对照大鼠的两倍。我们得出的结论是，在这种颞叶癫痫模型中，BLA 神经元反应性的增强涉及抑制的减少，但也可能包括兴奋的增加。
Several lines of evidence suggest that the amygdala is altered functionally in humans with temporal lobe epilepsy, but little is known about neuronal interactions in the amygdala of humans or animals with chronic epilepsy. Using extracellular and intracellular recordings in horizontal slices, we tested the hypothesis that changes in local circuitry in the basolateral amygdala (BLA) permanently enhance neuronal responsiveness in kainate-treated, epileptic rats. Population responses in the BLA to orthodromic stimulation were significantly enhanced, which was at least partly due to a decrease in local inhibition. In the presence of GABA receptor antagonists, population responses were about twice as robust in epileptic versus control rats. We conclude that the enhanced neuronal responsiveness of the BLA in this model of temporal lobe epilepsy involves decreased inhibition, but may also include increased excitation.