Visual predictions in the orbitofrontal cortex rely on associative content.
Visual predictions in the orbitofrontal cortex rely on associative content.
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DOI：
10.1093/cercor/bht146
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Bar, Moshe
中科院分区：
文献类型：
--
作者：
Chaumon, Maximilien;Kveraga, Kestutis;Bar, Moshe
从不完整的信息中预测即将发生的事件是大脑的一项基本功能。眶额皮层（OFC）在这一过程中起着至关重要的作用，通过预测反馈到感觉皮层促进对感觉输入的识别。在视觉领域，眶额皮层被低空间频率（LSF）和大细胞偏置输入所激活，但除此之外，我们对激活它所需的信息内容知之甚少。还是只有当LSF信息与先前存在的记忆关联相匹配时，它才被激活？我们测试了这些假设，并表明，只有LSF的信息，可以链接到记忆协会从事眶额皮层。具体来说，LSF刺激激活OFC在2个不同的内侧和外侧区域，只有当他们类似于已知的视觉对象。更多可识别的物体增加了内侧眶额皮层的活动，该皮层以其在情感反应中的功能而闻名。此外，这些物体还增加了外侧眶额皮层与腹侧视觉皮层的连接，腹侧视觉皮层是物体识别的关键区域。因此，在感觉、记忆和情感处理之间的界面上，眶额皮层似乎与视觉信息的关联内容相协调，并在视觉-情感预测中发挥核心作用。
Predicting upcoming events from incomplete information is an essential brain function. The orbitofrontal cortex (OFC) plays a critical role in this process by facilitating recognition of sensory inputs via predictive feedback to sensory cortices. In the visual domain, the OFC is engaged by low spatial frequency (LSF) and magnocellular-biased inputs, but beyond this, we know little about the information content required to activate it. Is the OFC automatically engaged to analyze any LSF information for meaning? Or is it engaged only when LSF information matches preexisting memory associations? We tested these hypotheses and show that only LSF information that could be linked to memory associations engages the OFC. Specifically, LSF stimuli activated the OFC in 2 distinct medial and lateral regions only if they resembled known visual objects. More identifiable objects increased activity in the medial OFC, known for its function in affective responses. Furthermore, these objects also increased the connectivity of the lateral OFC with the ventral visual cortex, a crucial region for object identification. At the interface between sensory, memory, and affective processing, the OFC thus appears to be attuned to the associative content of visual information and to play a central role in visuo-affective prediction.