n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and women.
n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and women.
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DOI：
10.3945/jn.113.174383
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
M. Kratz;J. Kuzma;D. Hagman;B. van Yserloo;C. Matthys;H. Callahan;D. Weigle
中科院分区：
文献类型：
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作者：
M. Kratz;J. Kuzma;D. Hagman;B. van Yserloo;C. Matthys;H. Callahan;D. Weigle
最近的研究表明，omega-3（n3）多不饱和脂肪酸（PUFA）可减少啮齿动物和病态肥胖人类的脂肪组织炎症。我们研究了富含来自海洋和植物来源的n3 PUFA的饮食是否会减少超重至中度肥胖成年人的脂肪组织和全身炎症。我们进行了一项随机、单盲、平行设计、安慰剂对照喂养试验。体重指数在28和33 kg/m2之间的健康男性和女性食用富含n3 PUFAs的饮食（3.5%的能量摄入; n = 11）来自植物和海洋来源或对照饮食（0.5%的能量摄入来自n3 PUFAs; n = 13）。这些饮食被消耗14周（自由采食12周）。在整个研究期间提供所有食物。皮下腹部脂肪组织和空腹血浆后，第2周与对照饮食，并再次在14周的饮食期结束时收集。这项事后分析的主要结果是13种关键炎症介质的脂肪组织基因表达。在调整体重变化后，两组之间脂肪组织炎症介质的基因表达没有差异。此外，5种全身性炎症的血浆标志物均未因饮食治疗而显著不同。我们得出结论，相对高剂量的植物和海洋来源的n3多不饱和脂肪酸并没有显着降低脂肪组织或全身炎症超重至中度肥胖的健康男性和女性超过14周。
Recent studies have indicated that omega-3 (n3) polyunsaturated fatty acids (PUFAs) decrease adipose tissue inflammation in rodents and in morbidly obese humans. We investigated whether a diet rich in n3 PUFAs from both marine and plant sources reduces adipose tissue and systemic inflammation in overweight to moderately obese adults. We conducted a randomized, single-blind, parallel-design, placebo-controlled feeding trial. Healthy men and women with a body mass index between 28 and 33 kg/m(2) consumed a diet rich in n3 PUFAs (3.5% of energy intake; n = 11) from plant and marine sources or a control diet (0.5% of energy intake from n3 PUFAs; n = 13). These diets were consumed for 14 wk (ad libitum for 12 wk). All foods were provided for the entire study period. Subcutaneous abdominal adipose tissue and fasting plasma were collected after the first 2 wk with the control diet and again at the end of the 14-wk dietary period. The primary outcome of this ex post analysis was the adipose tissue gene expression of 13 key mediators of inflammation. Adipose tissue gene expression of inflammatory mediators did not differ between the 2 groups, after adjustment for weight change. Furthermore, none of the 5 plasma markers of systemic inflammation differed significantly as an effect of diet treatment. We conclude that a relatively high dose of n3 PUFAs from plant and marine sources did not significantly lower adipose tissue or systemic inflammation in overweight to moderately obese healthy men and women over 14 wk.