High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians
High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians
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DOI：
10.1093/ajcn/85.4.1062
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发表时间：
2007-04-01
影响因子：
7.1
通讯作者：
Kumar, Ethamakula G. Tiruvenkata
中科院分区：
文献类型：
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作者：
Harinarayan, Chittari V.;Ramalakshmi, Tiritpati;Kumar, Ethamakula G. Tiruvenkata
背景：在像印度这样的热带国家，关于人口维生素D状况的数据很少被记录在案。目的：记录印度城市和农村人群的饮食习惯和血清钙、25-羟基维生素D[25(OH)D]和甲状旁腺激素的浓度。设计：对健康城市(n=943)和农村(n=205)受试者的膳食结构和血清钙、磷、碱性磷酸酶、25(OH)D和免疫活性甲状旁腺激素的浓度进行研究。结果：与印度医学研究委员会发布的推荐膳食摄入量相比，城市和农村人群的膳食钙摄入量均较低。农村成年人的膳食钙和磷显著低于城市成年人(P<；0.0001)。农村受试者膳食中植酸与钙的比例高于城市受试者(P<；0.0001)。无论男女，农村受试者的25(OH)D浓度均高于城市受试者(P<；0.001)。在农村受试者中，分别有44%、39.5%和16.5%的男性和70%、29%和1%的女性出现25(OH)D缺乏(<；20 ng/m L)、-不足(20-30 ng/m L)和-充分(>；30 ng/m L)状态。在城市受试者中，分别有62%、26%和12%的男性和75%、19%和6%的女性出现25(OH)D缺乏、-不足和-充分状态。结论：膳食钙摄入量低和25(OH)D浓度过低与骨矿物质平衡的不良影响有关。需要进行前瞻性纵向研究来评估对骨密度的影响，骨密度是骨折风险和骨折发生率的替代标记物。
Background: Data on the vitamin D status of the population in a tropical country such as India have seldom been documented. Vitamin D deficiency is presumed to be rare.Objective: The objective was to document the dietary habits and concentrations of serum calcium, 25-hydroxyvitamin D [25(OH)D], and parathyroid hormone of Indian urban and rural populations.Design: Healthy urban (n = 943) and rural (n = 205) subjects were studied for their dietary pattern and concentrations of serum calcium, phosphorus, alkaline phosphatase, 25(OH)D, and immunoreactive parathyroid hormone.Results: The daily dietary calcium intake of both the urban and rural populations was low compared with the recommended dietary allowances issued by the Indian Council of Medical Research. Dietary calcium and phosphorous were significantly lower in rural adults than in urban adults (P < 0.0001). The dietary phytate-to-calcium ratio was higher in rural subjects than in urban subjects (P < 0.0001). The 25(OH)D concentrations of the rural subjects were higher than those of urban subjects (P < 0.001), both men and women. In the rural subjects, 25(OH)D-deficient (< 20 ng/mL), -insufficient (20-30 ng/mL), and -sufficient (> 30 ng/mL) states were observed in 44%, 39.5%, and 16.5% of the men and 70%, 29%, and 1% of the women, respectively. In the urban subjects, 25(OH)D-deficient, -insufficient, and -sufficient states were observed in 62%, 26%, and 12% of the men and 75%, 19%, and 6% of the women, respectively.Conclusions: Low dietary calcium intake and 25(OH)D concentrations were associated with deleterious effects on bone mineral homeostasis. Prospective longitudinal studies are required to assess the effect on bone mineral density, a surrogate marker for fracture risk and fracture rates.