Cerasome as an Organic-Inorganic Vesicular Nanohybrid: Characterization of Cerasome-Forming Lipids having a Single or a Dual Trialkoxysilyl Head
Cerasome as an Organic-Inorganic Vesicular Nanohybrid: Characterization of Cerasome-Forming Lipids having a Single or a Dual Trialkoxysilyl Head
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DOI：
10.1023/b:jsst.0000047968.68111.dc
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发表时间：
2004-08
影响因子：
2.5
通讯作者：
Mineo Hashizume;H. Inoue;Kiyofumi Katagiri;A. Ikeda;J. Kikuchi
中科院分区：
文献类型：
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作者：
Mineo Hashizume;H. Inoue;Kiyofumi Katagiri;A. Ikeda;J. Kikuchi
从两个方面对有机-无机囊泡纳米杂化物Cerasomes在水介质中的形态进行了表征。首先，合成了一种头部含有两个三乙氧基硅基的新型Cerasome形成脂质，并研究了其物理性质。虽然从对胶束形成非离子表面活性剂Triton-X 100的囊泡塌陷行为评价的神经酰胺脂质体的形态稳定性远高于常规磷脂脂质体的形态稳定性，但对于来自双头和单头脂质的神经酰胺脂质体，稳定性彼此相当。另一方面，与单头脂质相比，双头脂质形成的Cerasome的表面性质更接近胶体二氧化硅颗粒，如zeta电位测量所示。其次，评价了介质pH对用单头脂质形成的Cerasome的形态稳定性的影响，并表现为获得Cerasome的形态稳定性的时间差。Cerasomes的这些形态特征可能主要是由于囊泡表面硅氧烷网络的发展。
Morphological characterization of the organic-inorganic vesicular nanohybrids, Cerasomes, was performed in aqueous media from two aspects. Firstly, a novel Cerasome-forming lipid having two triethoxysilyl groups in the head moiety was synthesized and the physical property of the Cerasome was investigated. While the morphological stability of the Cerasomes, as evaluated from the vesicular collapse behavior against a micelle-forming nonionic surfactant, Triton-X 100, was extremely higher than that of the conventional phospholipid liposome, the stabilities were comparable to each other for the Cerasomes derived from the dual- and single-head lipids. On the other hand, the surface property of the Cerasome formed with the dual-head lipid more closely resembled the colloidal silica particles rather than that derived from the single-head lipid, as suggested by zeta-potential measurements. Secondly, the effect of the media pH on the morphological stability of the Cerasome formed with the single-head lipid was evaluated and appeared as a time difference in obtaining the morphological stability of the Cerasome. These morphological characteristics of the Cerasomes could be mainly owing to the development of the siloxane network on the vesicular surface.