KAINIC ACID NEUROTOXICITY - EFFECT OF SYSTEMIC INJECTION ON NEUROTRANSMITTER MARKERS IN DIFFERENT BRAIN-REGIONS
KAINIC ACID NEUROTOXICITY - EFFECT OF SYSTEMIC INJECTION ON NEUROTRANSMITTER MARKERS IN DIFFERENT BRAIN-REGIONS
复制标题
DOI：
10.1016/0006-8993(81)90405-4
复制
发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
MALTHESORENSSEN, D
中科院分区：
文献类型：
--
作者：
HEGGLI, DE;AAMODT, A;MALTHESORENSSEN, D
全身注射红藻氨酸（12 mg/kg）会导致多个脑区坏死和神经元变性。在梨状皮层、杏仁复合体、海马体和隔膜中观察到最明显的影响。在这 4 个区域中观察到形态变化与一些神经递质标记物的变化之间存在良好的相关性。在梨状皮层和杏仁复合体中，L-谷氨酸的高亲和力摄取以及谷氨酸脱羧酶和胆碱乙酰转移酶活性均降低，而在海马和隔膜中，仅前 2 个标记物降低。在纹状体或苍白球中没有观察到任何这些神经递质标记物的形态变化或减少。在外侧丘脑和膝状体中可以证明明显的神经元变性，但这种变性并不伴随所测试的递质标记物的任何减少。
Systemic injection of kainic acid (12 mg/kg) induces necrosis and neuronal degeneration in several brain regions. The most pronounced effects were observed in the piriform cortex, amygdaloid complex, hippocampus and septum. A good correlation between morphological changes and changes in some neurotransmitter markers was observed in these 4 areas. High affinity uptake of L-glutamate, as well as glutamate decarboxylase and choline acetyltransferase activities were reduced in the piriform cortex and amygdaloid complex whereas in the hippocampus and septum only the first 2 markers were reduced. No morphological changes or decrease in any of these neurotransmitter markers were observed in striatum or globus pallidus. A pronounced neuronal degeneration could be demonstrated in lateral thalamus and geniculate body, but this degeneration was not accompanied by any decrease in the transmitter markers tested.