Tandem Nazarov cyclization-Michael addition sequence catalyzed by an Ir(III) complex
Tandem Nazarov cyclization-Michael addition sequence catalyzed by an Ir(III) complex
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DOI：
10.1021/ja058772o
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发表时间：
2006-04-26
影响因子：
15
通讯作者：
Eisenberg, R
中科院分区：
文献类型：
--
作者：
Janka, M;He, W;Eisenberg, R
描述了串联Nazarov环化/Michael加成过程的第一个实例。该序列被Ir[Me（CO）（dppe）（DIB）]2+有效催化，并以高非对映选择性发生，产生三个连续的立体中心。讨论了控制反应活性和非对映选择性的机理因素。
The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.