Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
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Bcl-6和Blimp-1最近被鉴定为CD 4 + T细胞和CD 8 + T细胞中效应和记忆分化的关键转录调节因子。Bcl-6和Blimp-1是B淋巴细胞效应分化和记忆分化的重要调节因子。新的发现意外地指出Bcl-6和Blimp-1调节轴是控制效应和记忆淋巴细胞分化和功能的普遍机制。Bcl-6和Blimp-1是拮抗性转录因子，可以作为细胞命运决定的自我增强遗传开关。然而，它们在不同淋巴细胞中的影响是复杂的。在这里，我们审查和研究的共同点和差异，这些转录因子在CD 4+滤泡辅助TFH淋巴细胞，效应CD 8 + T淋巴细胞和B淋巴细胞的功能。
Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of effector and memory differentiation in CD4+ T cells and CD8+ T cells. Bcl-6 and Blimp-1 were previously known to be critical regulators of effector and memory differentiation of B lymphocytes. The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. Bcl-6 and Blimp-1 are antagonistic transcription factors and can function as a self-reinforcing genetic switch for cell-fate decisions. However, their influences in different lymphocytes are complex. Here we review and examine the commonalities and differences in the functions of these transcription factors in CD4+ follicular helper TFH lymphocytes, effector CD8+ T lymphocytes and B lymphocytes.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
30.8
作者：
Bereshchenko, OR;Gu, W;Dalla-Favera, R
通讯作者：
Dalla-Favera, R
DOI：
10.1073/pnas.0811139106
发表时间：
2008-12-23
影响因子：
11.1
作者：
Brooks, David G.;Ha, Sang-Jun;Oldstone, Michael B. A.
通讯作者：
Oldstone, Michael B. A.
影响因子：
64.5
作者：
Fujita, N;Jaye, DL;Wade, PA
通讯作者：
Wade, PA
影响因子：
20.3
作者：
Allman, D;Jain, A;Staudt, LM
通讯作者：
Staudt, LM