Integrin associated proteins
Integrin associated proteins
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DOI：
10.1016/s0955-0674(98)80032-x
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Hemler, ME
中科院分区：
文献类型：
--
作者：
Hemler, ME
整合素细胞质结构域可以直接与几种不同的细胞骨架蛋白和细胞内信号分子相互作用。此外，整合素直接与其他跨膜结构相互作用，包括跨膜4超家族（TM4SF）蛋白。新的证据表明，TM4SF蛋白可能作为细胞外整合素a链域和细胞内信号分子（如磷脂酰肌醇4-激酶和蛋白激酶C）之间的连接物。
Integrin cytoplasmic domains may interact directly with serveral different cytoskeletal proteins and intracellular signaling molecules. Also, integrins interact directly with other transmembrane structures, including transmembrane-4 superfamily (TM4SF) proteins. New evidence suggests that TM4SF proteins may act as linkers between extracellular integrin a chain domains and intracellular signaling molecules, such as phosphatidylinositol 4-kinase and protein kinase C.