BREATHING AND UPPER AIRWAY CO2 IN REPTILES - ROLE OF THE NASAL AND VOMERONASAL SYSTEMS
BREATHING AND UPPER AIRWAY CO2 IN REPTILES - ROLE OF THE NASAL AND VOMERONASAL SYSTEMS
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DOI：
10.1152/ajpregu.1989.256.1.r91
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发表时间：
1989-01-01
影响因子：
--
通讯作者：
BALLAM, GO
中科院分区：
文献类型：
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作者：
COATES, EL;BALLAM, GO
在切断嗅神经或犁鼻神经之前和之后，测量了束带蛇（Thamnophissirtalis）对上呼吸道（UA）输送2%CO2的呼吸反应。通过将气管内T管插入声门，将UA（鼻腔和口腔）与吸入肺部的气源隔离。通过头室向UA给予CO2。对UA CO2的主要呼吸反应是呼吸频率（f）和每分钟通气量显著降低。f的降低是由停顿持续时间的显著增加引起的。潮气量、呼气持续时间和吸气持续时间不随UA CO2改变。f响应UA CO2被取消与嗅神经切断，而犁鼻神经切断显着增加的f抑郁症的幅度。这些结果表明，CO2敏感受体位于鼻上皮和嗅觉神经必须是完整的UA CO2 f反应进行观察。此外，犁鼻系统似乎调节对UA CO2的呼吸反应。
The ventilatory response of the garter snake, Thamnophis sirtalis, to 2% CO2 delivered to the upper airways (UA) was measured before and after the olfactory or vomeronasal nerves were transected. The UA (nasal cavities and mouth) were isolated from the gas source inspired into the lungs by inserting an endotracheal T tube into the glottis. CO2 was administered to the UA via a head chamber. The primary ventilatory response to UA CO2 was a significant decrease in ventilatory frequency (f) and minute ventilation. The decrease in f was caused by a significant increase in the pause duration. Tidal volume, expiratory duration, and inspiratory duration were not altered with UA CO2. The f response to UA CO2 was abolished with olfactory nerve transection, whereas vomeronasal nerve transection significantly increased the magnitude of the f depression. These results indicate that CO2-sensitive receptors are located in the nasal epithelium and that the olfactory nerves must be intact for the UA CO2 f response to be observed. In addition, the vomeronasal system appears to modulate the ventilatory response to UA CO2.