The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIV/AIDS in the Era of Antiretroviral Therapy.
The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIV/AIDS in the Era of Antiretroviral Therapy.
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DOI：
10.1155/2012/262471
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发表时间：
2012
影响因子：
1.7
通讯作者：
Patterson TF
中科院分区：
文献类型：
--
作者：
Patel PK;Erlandsen JE;Kirkpatrick WR;Berg DK;Westbrook SD;Louden C;Cornell JE;Thompson GR;Vallor AC;Wickes BL;Wiederhold NP;Redding SW;Patterson TF
抗逆转录病毒疗法（ART）对艾滋病毒患者机会性条件的影响继续演变。我们专门研究了215名艾滋病毒/艾滋病患者口咽念珠菌病（OPC）流行病学的变化。从口腔冲洗样品中评估酵母菌定植状态，并使用CHROMagar Candida进行初步酵母菌鉴定，并使用标准微生物学技术和/或分子测序进行确认。采用CHROMagar念珠菌琼脂稀释筛选法和CLSI微量肉汤稀释法测定对氟康唑的敏感性。176例（82%）患者定植，59例（27%）患者有症状性OPC。白色念珠菌是最常见的菌种，而念珠菌属则是最常见的菌种。glabrata和C.在29%的分离物中检测到都柏林菌。氟康唑敏感性下降发生在10%的分离株。以前的ART降低了OPC的风险，而吸烟增加了定植的风险。即使在艾滋病毒治疗取得进展的情况下，口腔酵母菌定植和症状性感染仍然很常见。C.白色念珠菌是最常见的菌种，但其他酵母菌也很普遍，可能对氟康唑的敏感性降低。
The impact of antiretroviral therapy (ART) on opportunistic conditions in HIV patients continues to evolve. We specifically studied the changing epidemiology of oropharyngeal candidiasis (OPC) in 215 HIV/AIDS patients. Status of yeast colonization was assessed from oral rinse samples, and preliminary yeast identification was made using CHROMagar Candida and confirmed with standard microbiological techniques and/or molecular sequencing. Susceptibility to fluconazole was determined by CHROMagar Candida agar dilution screening and CLSI broth microdilution. 176 (82%) patients were colonized and 59 (27%) patients had symptomatic OPC. Candida albicans was the most prevalent species, though C. glabrata and C. dubliniensis were detected in 29% of isolates. Decreased fluconazole susceptibility occurred in 10% of isolates. Previous ART reduced the risk of OPC, while smoking increased the risk of colonization. Oral yeast colonization and symptomatic infection remain common even with advances in HIV therapy. C. albicans is the most common species, but other yeasts are prevalent and may have decreased susceptibility to fluconazole.