Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations.
Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations.
复制标题
银杏叶制剂对人肝细胞中紫杉醇代谢的体外抑制作用。
DOI：
10.1080/19390210902861817
复制
发表时间：
2009
影响因子：
2.5
通讯作者：
Mathews,JamesM
中科院分区：
文献类型：
--
作者：
Etheridge,AmyS;Kroll,DavidJ;Mathews,JamesM
自20世纪80年代末以来，化疗引起的认知障碍，也称为“化疗”，已经成为接受癌症治疗的患者中公认的副作用。尽管接受紫杉醇和其他药物化疗的患者可以使用含有银杏的产品，但尚未充分探讨与该组合发生草药相互作用的可能性。本文报道银杏叶制剂在体外对人肝细胞紫杉醇代谢的抑制作用。银杏提取物的水解物（萜烯内酯浓度为10-100 mM）对紫杉醇的6α -羟基化产生剂量依赖性抑制，紫杉醇的6α -羟基化酶活性是临床应用中该药物清除的主要原因;母体提取物没有影响。与银杏的假定治疗益处相反，其与紫杉醇的同时使用可能导致化疗药物的血液水平升高，伴随着认知障碍的加重和与癌症治疗相关的其他毒性作用。
Since the late 1980s, chemotherapy-induced cognitive impairment, also known as “chemobrain”, has been a recognized side effect in patients undergoing cancer treatment . Although products containingGinkgo bilobamay be used by patients undergoing chemotherapy with paclitaxel and other agents, the potential for an herb–drug interaction with this combination has not been adequately explored. This report describes the inhibition of paclitaxel metabolism byGinkgopreparations in vitro in human hepatocytes. Hydrolyzate ofGinkgoextract (10–100 mM in terpene lactone concentration) caused a dose-dependent inhibition of the 6α -hydroxylation of paclitaxel, the enzymatic activity responsible for the majority of the clearance of that drug in clinical applications; parent extract had no effect. Contrary to the assumed therapeutic benefit ofGinkgo, its concomitant use with paclitaxel could result in elevated blood levels of the chemotherapeutic, with attendant exacerbation of cognitive impairment and other toxic effects associated with cancer therapy.