A novel subpopulation of primed T cells in the human fetus.
A novel subpopulation of primed T cells in the human fetus.
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DOI：
10.4049/jimmunol.152.6.3098
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发表时间：
1994-03
影响因子：
4.4
通讯作者：
J. Byrne;A. Stanković;M. Cooper
中科院分区：
文献类型：
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作者：
J. Byrne;A. Stanković;M. Cooper
原始T细胞和记忆T细胞分别表达高水平的RA或RO同种型CD 45。在人类发育过程中这两种CD 45亚型的T细胞表达的检查中，RO+RA-“记忆”T细胞在新生儿血液和脾脏中不常见，但在成人组织中约占T细胞的一半。这些预期的发现可能反映了新生儿的免疫幼稚。然而，令人惊讶的是，RO+ RA-T细胞在胎儿脾和早产儿的脐带血样品中相对丰富，分别占这些组织中T细胞的约25%和10%。RO+ RA-T细胞的这种早期外周波由CD 4和CD 8亚群中的多克隆T细胞组成。CD 4+表型的胎儿RO+细胞经常表达以高亲和力IL-2受体为特征的CD 25-α链亚基，并且能够响应于外源性IL-2而增殖。与成人的RO+记忆T细胞相比，胎儿T细胞对促有丝分裂抗CD 2和抗CD 3抗体无反应。我们的结论是，数据表明胚胎群体中存在具有无能特征的自身反应性T细胞克隆。
Virgin and memory T cells reciprocally express high levels of the RA or the RO isoforms of CD45, respectively. In an examination of T cell expression of these two CD45 isoforms during human development, the RO+RA- "memory" T cells were infrequent in the newborn blood and spleen, but comprised approximately half of the T cells in adult tissues. These anticipated findings probably reflect the immunologic naivete of the newborn. Surprisingly, however, RO+RA- T cells were relatively abundant in fetal spleen and in cord blood samples from premature births, comprising approximately 25% and 10% of the T cells in these tissues, respectively. This early peripheral wave of RO+RA- T cells was composed of polyclonal T cells in both the CD4 and CD8 subpopulations. The fetal RO+ cells of CD4+ phenotype frequently expressed the CD25-alpha chain subunits that characterize high affinity IL-2 receptors, and were able to proliferate in response to exogenous IL-2. In further contrast with their RO+ memory T cell counterparts in adults, the fetal T cells were unresponsive to mitogenic anti-CD2 and anti-CD3 antibodies. We conclude that the data suggest an embryonic population of autoreactive T cell clones with anergic characteristics.