Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology.
Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology.
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DOI：
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发表时间：
1999-08
影响因子：
1.2
通讯作者：
M. Haygood;Eric W. Schmidt;S. Davidson;D. Faulkner
中科院分区：
文献类型：
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作者：
M. Haygood;Eric W. Schmidt;S. Davidson;D. Faulkner
海洋无脊椎动物是多种生物活性代谢物的来源，具有作为药物和研究工具开发的巨大潜力。在许多情况下，已知或怀疑微生物是海洋无脊椎动物天然产物的生物合成来源。应用分子微生物学来研究这些关系将有助于基础生物学知识并促进这些宝贵资源的生物技术开发。产生苔藓抑素的苔藓虫 B. neritina 及其特定的共生体“Candidatus Endobugula sertula”构成了一种有前途的模型系统。另一个值得研究的丰富课题是列表海绵，它含有大量生物活性代谢物，其中一些源自细菌共生体。
Marine invertebrates are sources of a diverse array of bioactive metabolites with great potential for development as drugs and research tools. In many cases, microorganisms are known or suspected to be the biosynthetic source of marine invertebrate natural products. The application of molecular microbiology to the study of these relationships will contribute to basic biological knowledge and facilitate biotechnological development of these valuable resources. The bryostatin-producing bryozoan B. neritina and its specific symbiont "Candidatus Endobugula sertula" constitute one promising model system. Another fertile subject for investigation is the listhistid sponges that contain numerous bioactive metabolites, some of which originate from bacterial symbionts.