The regulation of RANKL by mechanical force
The regulation of RANKL by mechanical force
复制标题
DOI：
10.1007/s00774-020-01145-7
复制
发表时间：
2020-09
影响因子：
3.3
通讯作者：
Fumiyuki Sasaki;M. Hayashi;T. Ono;T. Nakashima
中科院分区：
文献类型：
--
作者：
Fumiyuki Sasaki;M. Hayashi;T. Ono;T. Nakashima
核因子-κB受体激活因子配体（RANKL）是破骨细胞分化和骨吸收的关键介质。成骨细胞系细胞（包括成骨细胞和骨细胞）表达RANKL，RANKL受几种不同因素的调节，包括激素、细胞因子和机械力。体内和体外分析表明，细胞膜上的各种类型的机械传感蛋白（即机械传感器）和细胞内机械信号蛋白通过可溶性因子（如硬化素、Wnt配体和RANKL）在成骨细胞、破骨细胞和骨细胞的分化和功能中发挥重要作用。本节概述了通过机械感应和机械转导调节RANKL表达的体内和体外证据。
Receptor activator of nuclear factor-κB ligand (RANKL) is a key mediator of osteoclast differentiation and bone resorption. Osteoblast-lineage cells including osteoblasts and osteocytes express RANKL, which is regulated by several different factors, including hormones, cytokines, and mechanical forces. In vivo and in vitro analyses have demonstrated that various types of mechanosensing proteins on the cell membrane (i.e. mechanosensors) and intracellular mechanosignaling proteins play essential roles in the differentiation and functions of osteoblasts, osteoclasts, and osteocytes via soluble factors, such as sclerostin, Wnt ligands, and RANKL. This section provides an overview of the in vivo and in vitro evidence for the regulation of RANKL expression by mechanosensing and mechanotransduction.