Silencing of R-Spondin1 increases radiosensitivity of glioma cells.
Silencing of R-Spondin1 increases radiosensitivity of glioma cells.
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R-Spondin1 沉默会增加神经胶质瘤细胞的放射敏感性。
作者：
Gu X;Wang X;Xiao H;Ma G;Cui L;Li Y;Zhou H;Liang W;Zhao B;Li K
虽然放疗是最有效的术后辅助治疗，但由于胶质瘤特有的放射耐药，放疗并不能显著改善胶质瘤患者的长期预后。我们发现R-Spondin1 （Rspo1）表达在高级别胶质瘤中升高，并且与较差的总生存期和无病生存期相关。在接受放疗和替莫唑胺（RT-TMZ）治疗的胶质瘤患者中，Rspo1表达也与生存率降低有关。重要的是，在胶质瘤患者放射治疗后，Rspo1显著上调。shRNA沉默Rspo1可增强放射治疗后胶质瘤细胞的死亡。在异种移植裸鼠模型中，结合放射和沉默Rspo1增强肿瘤生长抑制。因此，将放疗与Rspo1沉默相结合是一种潜在的治疗方法。
Although radiation therapy is the most effective postoperative adjuvant treatment, it does not substantially improve the long-term outcomes of glioma patients because of the characteristic radioresistance of glioma. We found that R-Spondin1 (Rspo1) expression was elevated in high-grade gliomas and was associated with worse overall survival and disease-free survival. Rspo1 expression was also associated with reduced survival rates in glioma patients after treatment with radiotherapy and temozolomide (RT-TMZ). Importantly, Rspo1 was dramatically upregulated after radiation treatment in patients with glioma. Rspo1 silencing by shRNA potentiated glioma cell death upon radiation treatment. In a xenograft nude mouse model, combining radiation and silencing of Rspo1 potentiated tumor growth inhibition. Thus, combining radiotherapy with silencing of Rspo1 is a potential therapeutic approach.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
15.9
作者：
Gu, Xuefeng;Yao, Lifen;Li, Keshen
通讯作者：
Li, Keshen
DOI：
10.1016/0360-3016(79)90553-4
发表时间：
1979-01-01
影响因子：
7
作者：
WALKER, MD;STRIKE, TA;SHELINE, GE
通讯作者：
SHELINE, GE
影响因子：
51.1
作者：
Stupp, Roger;Hegi, Monika E.;Mirimanoff, Rene-Olivier
通讯作者：
Mirimanoff, Rene-Olivier
影响因子：
4.8
作者：
Wei, Qiou;Yokota, Chika;He, Xi
通讯作者：
He, Xi