Disturbance of syncytial cell function in glomerular mesangial cells involved in the progressive glomerular diseases.
Disturbance of syncytial cell function in glomerular mesangial cells involved in the progressive glomerular diseases.
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DOI：
10.1159/000071733
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发表时间：
2003
影响因子：
--
通讯作者：
T. Oite;Jian Yao;T. Morioka
中科院分区：
文献类型：
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作者：
T. Oite;Jian Yao;T. Morioka
到目前为止，人们一直认为肾小球血流动力学改变或肾小球生长反应可能促进肾小球硬化的发展，而与病因无关[1，2]。然而，导致进行性肾小球硬化的细胞和分子机制仍不清楚。在这里，我们提出了进行性肾小球硬化发病机制的新概念，基于我们和其他人工作中积累的证据。
Until now it has been proposed that glomerular hemodynamic changes or glomerular growth response may promote the development of glomerulosclerosis, irrespective of etiology [1, 2]. However, the cellular and molecular mechanisms leading to progressive glomerulosclerosis still remain unclear. Here, we present a new concept of the pathogenesis of progressive glomerulosclerosis, based on the accumulating evidence obtained from our work and that of others.