CORONARY-ARTERY EMBOLIZATION IN CLOSED-CHEST CANINES USING FLEXIBLE RADIOPAQUE PLUGS
CORONARY-ARTERY EMBOLIZATION IN CLOSED-CHEST CANINES USING FLEXIBLE RADIOPAQUE PLUGS
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DOI：
10.1152/jappl.1988.64.5.2236
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发表时间：
1988-05-01
影响因子：
3.3
通讯作者：
MORRIS, DL
中科院分区：
文献类型：
--
作者：
HERR, MD;MCINERNEY, JJ;MORRIS, DL
一种新技术通过在冠状动脉中放置离散的塞子而无需使用笨重的同轴导管或导丝，从而在闭胸犬中诱发局部心肌梗塞。这种方法所必需的柔性塞子是通过将牙科印模聚合物（用碘化钠使其不透射线）挤压成意大利面条状的线而形成的。这些股线的片段可以通过导管注射到选定的冠状动脉中。接触血液或盐水会导致栓塞肿胀。由于溶胀导致的塞子直径的平均增加是27±。 20%。通过颈动脉入路对 8 只麻醉犬进行栓塞 [6 只左前降支 (LAD)、1 只左回旋支 (LCX)、1 只 LAD 和 LCX]。通过荧光镜监测插头位置。一只动物在栓塞后 2 天死亡。其余七只狗在 14-37 天后被杀死。尸检显示血管完全闭塞和局部梗塞。由一个、两个或三个塞子阻塞冠状动脉引起的梗塞涉及左心室质量的 2-26%。
A new technique induces localized myocardial infarction in closed-chest dogs by placing discrete plugs in coronay arteries without using cumbersome coaxial catheters or guide wires. Flexible plugs, essential to this method, are formed by extruding a dental impression polymer, rendered radiopaque with sodium iodide, into spaghetti-like strands. Segments of these strands can be injected through a catheter into a selected coronary artery. Contact with blood or saline causes plugs to swell. The mean increase in plug diameter due to swelling was 27 .+-. 20%. Eight anesthetized dogs were embolized via carotid approach [6 left anterior descending (LAD), 1 left circumflex (LCX), and 1 LAD and LCX]. Plug positions were monitored fluoroscopically. One animal died at 2 days postembolization. The remaining seven dogs were killed after 14-37 days. Autopsies showed complete vessel occlusion and localized infarction. Infarcts resulting from coronary artery occlusion with one, two, or three plugs involved 2-26% of the left ventricular mass.