Sindbis virus - an effective targeted cancer therapeutic
Sindbis virus - an effective targeted cancer therapeutic
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DOI：
10.1016/j.tibtech.2004.08.002
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发表时间：
2004-10-01
影响因子：
17.3
通讯作者：
Hay, JG
中科院分区：
文献类型：
--
作者：
Hay, JG
用于癌症治疗的病毒疗法具有许多潜在的积极属性。这些包括特异性感染靶细胞的能力，特异性表达毒性或免疫增强基因的能力，以及在肿瘤细胞内特异性复制的能力。尽管有这些生物学优势，但迄今为止的疗效有限。最近的一份报告表明，辛德比斯病毒在基因治疗的三个具有挑战性的领域-特异性，有效性和递送方面具有显着的特性，这表明辛德比斯有潜力成为癌症治疗的重要基因治疗载体。
Viral therapies for cancer therapy have many potential positive attributes. These include the ability to specifically infect targeted cells, specifically express toxic or immune-enhancing genes, and the ability to specifically replicate within a tumor cell. Despite these biological advantages, efficacy to date has been limited. A recent report demonstrates that the Sindbis virus has remarkable properties in three challenging areas of gene therapy - specificity, efficacy and delivery, suggesting that Sindbis has the potential to become an important gene therapy vector for cancer therapy.