Antibiotic Resistance: One Health One World Outlook.
Antibiotic Resistance: One Health One World Outlook.
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DOI：
10.3389/fcimb.2021.771510
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发表时间：
2021
影响因子：
5.7
通讯作者：
Baloch Z
中科院分区：
文献类型：
--
作者：
Aslam B;Khurshid M;Arshad MI;Muzammil S;Rasool M;Yasmeen N;Shah T;Chaudhry TH;Rasool MH;Shahid A;Xueshan X;Baloch Z
抗生素耐药性（ABR）是全球日益增长的公共卫生问题，现在被视为一个关键的健康问题。One Health的相互关联的领域有助于耐药性微生物在地方和全球范围内的出现、进化和传播，这是全球健康的一个重大风险因素。耐药微生物物种的持续存在和传播，以及人类-动物-环境界面上决定因素的关联可以改变微生物基因组，从而在各种生态位中产生耐药超级细菌。ABR的动机是三个领域之间建立了良好的联系：人类，动物和环境健康。因此，通过一个健康方法解决ABR是有意义的。一些国家根据粮食及农业组织（粮农组织）-世界动物卫生组织（兽疫局）-世界卫生组织（世卫组织）三方承诺准则，实施了基于“一个健康”办法的国家行动计划，以防治抗药性微生物。ABR已被确定为全球健康问题，目前正在努力减轻这一全球健康威胁。总而言之，需要基于同一健康原则的全球跨学科和统一方法来限制ABR传播周期，提高对抗生素使用的认识和教育，并促进政策，宣传和抗菌药物管理。
Antibiotic resistance (ABR) is a growing public health concern worldwide, and it is now regarded as a critical One Health issue. One Health’s interconnected domains contribute to the emergence, evolution, and spread of antibiotic-resistant microorganisms on a local and global scale, which is a significant risk factor for global health. The persistence and spread of resistant microbial species, and the association of determinants at the human-animal-environment interface can alter microbial genomes, resulting in resistant superbugs in various niches. ABR is motivated by a well-established link between three domains: human, animal, and environmental health. As a result, addressing ABR through the One Health approach makes sense. Several countries have implemented national action plans based on the One Health approach to combat antibiotic-resistant microbes, following the Tripartite’s Commitment Food and Agriculture Organization (FAO)-World Organization for Animal Health (OIE)-World Health Organization (WHO) guidelines. The ABR has been identified as a global health concern, and efforts are being made to mitigate this global health threat. To summarize, global interdisciplinary and unified approaches based on One Health principles are required to limit the ABR dissemination cycle, raise awareness and education about antibiotic use, and promote policy, advocacy, and antimicrobial stewardship.