Role of inflammation in atherosclerosis associated with rheumatoid arthritis
Role of inflammation in atherosclerosis associated with rheumatoid arthritis
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DOI：
10.1016/j.amjmed.2008.06.014
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发表时间：
2008-10-01
影响因子：
5.9
通讯作者：
Libby, Peter
中科院分区：
文献类型：
--
作者：
Libby, Peter
风湿性关节炎（RA）与心肌梗死和相关疾病的高发病率和死亡率有关。大量证据支持常见的促炎细胞因子参与RA和动脉粥样硬化的发生和进展。RA中涉及的破坏性促炎级联反应和效应器机制类似于驱动动脉粥样硬化发展的慢性炎症过程。RA局部受累关节内产生的促炎细胞因子如白细胞介素（IL）-1，IL-6和肿瘤坏死因子-α可能促进传统（例如，血脂异常，胰岛素抵抗）和非传统的（例如，氧化应激）全身性心血管危险因素。促炎细胞因子和炎性介质的表达影响动脉粥样硬化发展的所有阶段，从早期动脉粥样硬化形成到血栓发展，导致诸如心肌梗死的事件。对RA和动脉粥样硬化共同的炎症过程的认识应提高对这种病态关联的认识，并导致更好地认识和管理风湿性疾病患者的心血管风险。(C)2008年爱思唯尔公司All rights reserved.
Rheumatoid arthritis (RA) is associated with excess morbidity and mortality from myocardial infarction and allied disorders. A large body of evidence supports the involvement of common proinflammatory cytokines in the development and progression of both RA and atherosclerosis. The destructive proinflammatory cascade and effector mechanisms implicated in RA resemble the chronic inflammatory processes that drive the development of atherosclerosis in general. Proinflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha produced within locally affected joints in RA may promote both traditional (e.g., dyslipidemia, insulin resistance) and nontraditional (e.g., oxidative stress) systemic cardiovascular risk factors. Expression of proinflammatory cytokines and inflammatory mediators influences all stages of atherosclerosis development, from early atheroma formation to thrombus development responsible for events such as myocardial infarction. Appreciation of the inflammatory process shared by RA and atherosclerosis should heighten the recognition of this morbid association and lead to better recognition and management of cardiovascular risk in patients with rheumatologic diseases. (C) 2008 Elsevier Inc. All rights reserved.