4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor α agonists
4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor α agonists
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DOI：
10.1016/s0960-894x(00)00244-4
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发表时间：
2000-06-19
影响因子：
2.7
通讯作者：
Zhang, XK
中科院分区：
文献类型：
--
作者：
Dawson, MI;Jong, L;Zhang, XK
具有间位取代的芳环桥的芳族类视色素，例如4-[3-（5，6，7，8-四氢-5，5，8，8-四甲基-2-萘基）苯基]苯甲酸及其3，5-二芳基取代的4，5-二氢异恶唑类似物，通过激活视色素酸和类视色素X受体以诱导基因转录而起类视色素受体全激动剂的作用，从而为类视色素药物开发提供新的支架。这两类配体诱导型转录因子都参与介导类维生素A对癌细胞生长的抑制作用。(C)2000爱思唯尔科技有限公司版权所有。
Aromatic retinoids having a meta-substituted aromatic ring bridge, such as 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and its 3,5-diaryl-substituted 4,5-dihydroisoxazole analogue, function as retinoid receptor panagonists by activating both retinoic acid and retinoid X receptors to induce gene transcription, and thereby provide novel scaffolds for retinoid drug development. Both classes of these ligand-inducible transcription factors are involved in mediating the inhibitory effects of retinoids on cancer cell growth. (C) 2000 Elsevier Science Ltd. All rights reserved.