Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
复制标题
DOI：
10.1038/sj.ijo.0800818
复制
发表时间：
1999-03-01
影响因子：
4.9
通讯作者：
Hellström, PM
中科院分区：
文献类型：
--
作者：
Näslund, E;Barkeling, B;Hellström, PM
背景技术背景：对正常体重和肥胖的人外周给予胰高血糖素样肽-1（GLP-1）4小时，减少食物摄入并抑制食欲。目的：本研究的目的是评估8小时输注GLP-1对肥胖受试者午餐和晚餐食欲和能量摄入的影响。设计：随机、盲法交叉设计，静脉输注GLP-1（0.75 pmol . kg（-1）。受试者：8名肥胖（体重指数，BMI，45.5 +/- 2.3 kg/m2）男性受试者。测量：在08.00 h能量固定早餐（2.4MJ）后，在午餐（12.00 h）和晚餐（16.00 h）随意摄入能量。使用视觉模拟量表（VAS）在餐前和餐后即刻以及餐间每小时评估食欲。用于分析葡萄糖、胰岛素、C肽、GLP-1和肽YY的血样。胃排空早餐和午餐后使用扑热息痛吸收technique.Results：饥饿评级显着塔GLP-1输液。通过GLP-1输注，午餐和晚餐的自由采食量总和减少了1.7 +/- 0.5 MJ（21 +/- 6%）（P= 0.01）。GLP-1输注延迟胃排空，血糖浓度降低（基线：6.6+/-0.35 mmol/L;最低值：5.3+/-0.15 mmol/L）。GLP-1 infrations.CONCLUSIONS：我们的研究结果表明，GLP-1减少饥饿感，减少肥胖人群的能量摄入。这一发现的一个可能机制可能是增加饱腹感主要由胃迷走神经传入信号介导。
BACKGROUND: Peripheral administration of glucagon-like peptide-1 (GLP-1) for four hours, to normal weight and obese humans, decreases food intake and suppresses appetite.OBJECTIVE: The aim of this study was to assess the effect of an eight hour infusion of GLP-1 on appetite and energy intake at lunch and dinner in obese subjects.DESIGN: Randomised, blinded cross-over design with intravenous infusion of GLP-1 (0.75 pmol . kg(-1) . min(-1)) or saline.SUBJECTS: Eight obese (body mass index, BMI, 45.5 +/- 2.3 kg/m(2)) male subjects.MEASUREMENTS: Ad libitum energy intake at lunch (12.00 h) and dinner (16.00 h) after an energy fixed breakfast (2.4MJ) at 08.00 h. Appetite sensations using visual analogue scales, (VAS) immediately before and after meals and hourly in-between. Blood samples for the analysis of glucose, insulin, C-peptide, GLP-1 and peptide YY. Gastric emptying after breakfast and lunch using a paracetamol absorption technique.RESULTS: Hunger ratings were significantly Tower with GLP-1 infusion. The summed ad libitum energy intake at lunch and dinner was reduced by 1.7 +/- 0.5 MJ (21 +/- 6%) by GLP-1 infusion (P= 0.01). Gastric emptying was delayed by GLP-1 infusion, and plasma glucose concentrations decreased (baseline: 6.6+/-0.35mmol/L; nadir: 5.3+/-0.15mmol/L). No nausea was recorded during GLP-1 infusion.CONCLUSIONS: Our results demonstrate that GLP-1 decreases feelings of hunger and reduces energy intake in obese humans. One possible mechanism for this finding might be an increased satiety primarily mediated by gastric vagal afferent signals.