Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance.
Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance.
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DOI：
10.1155/2016/8239258
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发表时间：
2016
影响因子：
4.1
通讯作者：
Sousa LP
中科院分区：
文献类型：
--
作者：
Sugimoto MA;Vago JP;Teixeira MM;Sousa LP
中性粒细胞（也称为多形核白细胞或 PMN）是免疫系统的重要组成部分，可快速招募到炎症部位，提供抵御入侵病原体的第一道防线。由于中性粒细胞也会引起组织损伤，因此它们在炎症部位的微调调节对于炎症的正确解决是必需的。膜联蛋白 A1 (AnxA1) 也称为脂皮质素-1，是一种内源性糖皮质激素调节蛋白，能够对抗炎症事件，恢复体内平衡。 AnxA1 及其模拟肽通过减少白细胞浸润和激活中性粒细胞凋亡来抑制中性粒细胞组织积累。 AnxA1 还促进单核细胞募集和巨噬细胞清除凋亡白细胞。最近，一些证据表明 AnxA1 能够诱导巨噬细胞重编程为消退表型，从而减少促炎细胞因子的产生并增加免疫抑制和促消退分子的释放。这些机制的结合可以有效解决炎症，表明 AnxA1 作为开发治疗炎症性疾病的新治疗策略的有前途的工具。
Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components of the immune system, rapidly recruited to sites of inflammation, providing the first line of defense against invading pathogens. Since neutrophils can also cause tissue damage, their fine-tuned regulation at the inflammatory site is required for proper resolution of inflammation. Annexin A1 (AnxA1), also known as lipocortin-1, is an endogenous glucocorticoid-regulated protein, which is able to counterregulate the inflammatory events restoring homeostasis. AnxA1 and its mimetic peptides inhibit neutrophil tissue accumulation by reducing leukocyte infiltration and activating neutrophil apoptosis. AnxA1 also promotes monocyte recruitment and clearance of apoptotic leukocytes by macrophages. More recently, some evidence has suggested the ability of AnxA1 to induce macrophage reprogramming toward a resolving phenotype, resulting in reduced production of proinflammatory cytokines and increased release of immunosuppressive and proresolving molecules. The combination of these mechanisms results in an effective resolution of inflammation, pointing to AnxA1 as a promising tool for the development of new therapeutic strategies to treat inflammatory diseases.