Localized Light-Au-Hyperthermia Treatment for Precise, Rapid, and Drug-Free Blood Clot Lysis
Localized Light-Au-Hyperthermia Treatment for Precise, Rapid, and Drug-Free Blood Clot Lysis
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局部光金热疗可实现精确、快速、无药物的血凝块溶解
DOI：
10.1021/acsami.8b20616
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发表时间：
2019-01-16
影响因子：
9.5
通讯作者：
Wang, Xiaolei
中科院分区：
文献类型：
--
作者：
Dong, Lina;Liu, Xiao;Wang, Xiaolei
血栓性疾病通常是由血瘀证或血管栓塞术引起的，在世界范围内经常发生，致残率和死亡率都很高。目前，药物溶栓是临床上主要的血栓溶解治疗方法，当全身过度使用溶栓剂时，会增加出血的致死性风险。因此，一种基于远程物理信号的新型、先进的血栓溶解治疗方法有助于辅助临床治疗。在这里，我们使用金纳米棒(金纳米棒)在近红外光(808 Nm)照射下诱导的局部光-金-热疗(LAH)治疗，用于精确、快速和无药物的血栓溶解。LAH技术首次被引入到小鼠血肿模型和小鼠心肌梗死模型中，用于溶解血栓。在小鼠血肿模型中，与传统疗法相比，LAH具有精确的、局部的热疗作用，可以缩短消肿时间。同时，我们还发现在小鼠心肌梗死模型中，LAH有利于血管再通。此外，用于LAH的Au NRS在小鼠模型中表现出理想的生物相容性，这使其适合于体内血栓溶解。
Thrombus diseases, induced by blood stasis or vascular embolization normally, frequently occur with high disability and mortalities worldwide. At present, drug thrombolysis, a primary clinical therapy for blood clot lysis, could increase the lethal risk for hemorrhage when thrombolysis agents are overused in the whole body. Therefore, a novel and advanced therapy for blood clot lysis, based on remote physical signals, is helpful for assisting clinical therapy. Here, we used the localized light-Au-hyperthermia (LAH) treatment, induced by gold nanorods (Au NRs) irradiated with near-infrared light (808 nm), for precise, rapid, and drug-free blood clot lysis. The LAH technology was first introduced in the murine hematoma model and the murine myocardial infarction model for blood clot lysis. Compared with traditional therapy, LAH was assured to shorten the time of detumescence in the murine hematoma model owing to their precise and localized hyperthermia. Meanwhile, we also discovered that LAH was a benefit to vascular recanalization in the murine myocardial infarction model. In addition, the Au NRs used in LAH present ideal biocompatibility in the murine model, which endows it to be suitable for blood clot lysis in vivo.