THE EFFECTS OF ETHANOL AND DIAZEPAM ON REACTIONS TO PREDATORY ODORS
THE EFFECTS OF ETHANOL AND DIAZEPAM ON REACTIONS TO PREDATORY ODORS
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DOI：
10.1016/0091-3057(90)90357-n
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发表时间：
1990-04-01
影响因子：
3.6
通讯作者：
MEYER, S
中科院分区：
文献类型：
--
作者：
BLANCHARD, RJ;BLANCHARD, DC;MEYER, S
在有猫味刺激的笔直巷子里，大鼠表现出很高的风险评估率，包括平背接近和伸展注意行为，倾向于威胁刺激和接触刺激。在这种情况下，安定(2.0和4.0 mg/kg)显著减少了风险评估措施(平背入路+伸展训练)，但不能可靠地改变控制运动(弯曲背部)。结合早期的发现，相同剂量的安定可靠地增加了运动停止基线的风险评估，这些结果有力地支持了焦虑的行为模型，该模型涉及作为焦虑减少的功能的风险评估的可预测的非单调变化。与安定相比，乙醇在猫气味测试中的影响不那么明显，就像在早期对潜在威胁的反应任务中一样。然而，可靠的剂量。次数。风险评估措施的时间交互作用表明，乙醇的影响与安定相似，但在测试阶段的初始阶段最为明显。
In a straight alley containing a cat odor stimulus rats show high rates of risk assessment, including flat back approach and stretch attend behaviors oriented toward that threat stimulus and contact with the stimulus. In this situation, diazepam (2.0 and 4.0 mg/kg) significantly reduced risk assessment measures (flat back approach + stretch attend), while not reliably altering control locomotion (curved back). In combination with earlier findings that the same doses of diazepam reliably increased risk assessment from a movement arrest baseline, these results strongly support a behavioral model of anxiety involving predictable nonmonotonic changes in risk assessment as a function of anxiety reduction. In comparison to diazepam, ethanol had less pronounced effects on the Cat Odor Test, as in earlier tasks of reactivity to potential threat. However, reliable dose .times. time interactions for risk assessment measures suggest ethanol effects similar to those of diazepam but most pronounced in initial stages in the test session.