SERIAL MAGNETIC-RESONANCE-IMAGING OF EXPERIMENTAL ATHEROSCLEROSIS DETECTS LESION FINE-STRUCTURE, PROGRESSION AND COMPLICATIONS IN-VIVO
SERIAL MAGNETIC-RESONANCE-IMAGING OF EXPERIMENTAL ATHEROSCLEROSIS DETECTS LESION FINE-STRUCTURE, PROGRESSION AND COMPLICATIONS IN-VIVO
复制标题
DOI：
10.1038/nm0195-69
复制
发表时间：
1995-01-01
期刊：
影响因子：
82.9
通讯作者：
ROSS, R
中科院分区：
文献类型：
--
作者：
SKINNER, MP;YUAN, C;ROSS, R
动脉粥样硬化病变研究中的一个主要问题是难以对病变进行无创成像并跟踪其体内进展。为了解决这个问题，我们开发了先进的磁共振技术，可以对兔子腹主动脉中动脉粥样硬化的晚期病变进行无创和连续成像。管腔和管壁均以高分辨率成像。可以检测到导致病变质量增加、动脉管腔减少或狭窄以及病变内并发症的疾病进展。体内获得的图像与动脉粥样硬化病变的精细结构相关，包括纤维帽、坏死核心和病变裂隙，经大体检查、解剖显微镜和组织学验证。非侵入性识别动脉粥样硬化斑块特征的能力对于确定与不同治疗方法相关的风险和益处具有重要意义。
A major problem in the study of lesions of atherosclerosis is the difficulty of imaging noninvasively the lesions and following their progression in vivo. To address this problem, we have developed advanced magnetic resonance techniques to noninvasively and serially image advanced lesions of atherosclerosis in the rabbit abdominal aorta. Both lumen and wail were imaged with high resolution. Progression of disease, resulting in increase in lesion mass, decrease in arterial lumen, or stenosis, and intralesion complications, can be detected. Images acquired in vivo correlate with the fine structure of the lesions of atherosclerosis, including the fibrous cap, necrotic core, and lesion fissures, as verified by gross examination, dissection microscopy, and histology. The ability to noninvasively identify the features of atherosclerotic plaques, has significant implications for determining risks and benefits associated with different therapeutic approaches.