Home collection for frequent HIV testing: acceptability of oral fluids, dried blood spots and telephone results
Home collection for frequent HIV testing: acceptability of oral fluids, dried blood spots and telephone results
复制标题
DOI：
10.1097/00002030-200008180-00018
复制
发表时间：
2000-08-18
期刊：
影响因子：
3.8
通讯作者：
Gross, M
中科院分区：
文献类型：
--
作者：
Spielberg, F;Critchlow, C;Gross, M
目的：评估两个月一次的家庭口服液（OF）和干血斑（DBS）采集用于高危人群HIV检测的可行性和可接受性。设计：共有241名参与者[包括男男性行为者（MSM）、注射吸毒者（IDU），和有异性恋风险的妇女]从HIV预防试验网络（HIVNET）队列的四个研究中心招募的随机选择的研究参与者子集中招募，并在6个月的时间间隔内随机分配两个月一次的OF或DBS样本的家庭收集。参与者可以选择电话或诊所访问接收HIV检测results.Methods：每两个月标本进行跟踪，以遵守时间表，进行评估，充分的测试，并测试使用抗体检测和聚合酶链反应（PCR）DBS。双月的家庭OF和DBS收集和电话咨询的可接受性进行了评估，在结束的研究questionnaire.Results：实验室收到96和90%的预期OF和DBS标本，分别为99%的每种标本类型是足够的测试。几乎所有（95%）的参与者选择通过电话公布结果。大多数参与者（85%）报告说，每两个月检测一次并没有让他们更担心艾滋病毒，几乎所有人（98%）都认为，每两个月检测一次，他们的风险行为保持不变（77%）或风险降低（21%）。
Objective: To assess the feasibility and acceptability of bimonthly home oral fluid (OF) and dried blood spot (DBS) collection for HIV testing among high-risk individuals.Design: A total of 241 participants [including men who have sex with men (MSM), injecting drug users (IDU), and women at heterosexual risk] were recruited from a randomly selected subset of study participants enrolled at four sites in the HIV Network for Prevention Trials (HIVNET) cohort, and assigned at random to bimonthly home collection of OF or DBS specimens over a 6 month interval. Participants could select telephone calls or clinic visits to receive HIV test results.Methods: Bimonthly specimens were tracked for adherence to the schedule, were evaluated for adequacy for testing, and tested using antibody assays and polymerase chain reaction (PCR) for DBS. The acceptability of bimonthly home OF and DBS collection and telephone counseling was assessed in an end-of-study questionnaire.Results: The laboratory received 96 and 90% of expected OF and DBS specimens, respectively; 99% of each specimen type was adequate for testing. Almost all (95%) participants chose results disclosure by telephone. The majority of participants (85%) reported that bimonthly testing did not make them worry more about HIV, and almost all (98%) judged that with bimonthly testing their risk behavior remained the same (77%) or became less risky (21%).