Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
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DOI：
10.7326/l17-0527
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发表时间：
2018-01
影响因子：
39.2
通讯作者：
Abraham J. Kandathil;David L. Thomas;A. Balagopal
中科院分区：
文献类型：
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作者：
Abraham J. Kandathil;David L. Thomas;A. Balagopal
回应：我们非常感谢唐博士、王博士和坎多蒂博士及同事提供的有关HHpgV-1流行情况的宝贵信息。丙型肝炎病毒和HHpgV-1之间的强烈联系令人着迷。像唐博士和王博士一样，我们假设可能存在病毒相互依赖，就像对乙肝和丁型肝炎病毒所理解的那样。我们报道的在没有丙型肝炎病毒RNA的情况下持续复制HHpgV-1的明显例子证明，HHpgV-1不需要丙型肝炎病毒复制，但留下了其他流行病学和可能的病毒学解释。正如唐博士和王博士以及坎多蒂博士及其同事所评论的那样，进一步的研究可能有助于阐明HHpgV-1与丙型肝炎病毒之间的关系，并将从更广泛的角度提高我们对HHpgV-1感染的理解。
IN RESPONSE: We greatly appreciate the additional valuable information on the prevalence of HHpgV-1 provided by Drs. Tang and Wang and Dr. Candotti and colleagues. The strong association between HCV and HHpgV-1 is fascinating. Like Drs. Tang and Wang, we hypothesized that there might be viral codependence, as is appreciated for hepatitis B and D virus. The clear example that we reported of sustained HHpgV-1 replication in the absence of HCV RNA proves that HCV replication is not required for HHpgV-1 but leaves open other epidemiologic, and possibly virologic, explanations. As Drs. Tang and Wang and Dr. Candotti and colleagues comment, further studies may help to illuminate the relationship between HHpgV-1 and HCV and will more generally improve our understanding of HHpgV-1 infection.