Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone
Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone
复制标题
DOI：
10.1002/jbm.b.20034
复制
发表时间：
2004-04-15
影响因子：
3.4
通讯作者：
Nagayama, M
中科院分区：
文献类型：
--
作者：
Momota, Y;Miyamoto, Y;Nagayama, M
据报道，羟基磷灰石（HAP）腻子具有良好的止血能力和优异的生物相容性。虽然 RAP 腻子的凝固反应以及由此产生的 HAP 转化是其优异的生物相容性的原因，但它也限制了处理周期。本研究以中性磷酸氢钠浓度和后配制时间为指标，考察HAP腻子的凝固反应与其止血能力的关系。发现较高浓度的中性磷酸氢钠会导致止血能力下降。 HAP腻子制备后随时间的延长止血能力下降；因此，HAP腻子在配制后10分钟内使用非常重要。 HAP腻子对骨的粘合强度随着时间的推移而增加。因此，HAP 腻子可以实现可靠的止血。尽管有限的处理时间是一个缺点，但HAP腻子被认为具有作为止血剂的良好潜力——它高度可靠，并且具有高止血能力和优异的生物相容性。 (C) 2004 年 Wiley 期刊公司。
Hydroxyapatite (HAP) putty has been reported to have good hemostatic ability and excellent biocompatibility. Although the setting reaction of RAP putty and resulting transformation to HAP is the reason for this excellent biocompatibility, it also limits the handling period. In this study, the relationship between the setting reaction of HAP putty and its hemostatic ability was investigated, where neutral sodium hydrogen phosphate concentration and postpreparation time were used as indexes. A higher concentration of neutral sodium hydrogen phosphate was found to result in decreased hemostatic ability. The hemostatic ability of HAP putty decreased with time after its preparation; thus it was important to use HAP putty within 10 min after its preparation. The adhesive strength of HAP putty to bone increased with time. Therefore reliable hemostasis can be expected with HAP putty. Although the limited handling time is a drawback, HAP putty is thought to have a good potential as a hemostatic agent-it is highly reliable, and has a high hemostatic ability with excellent biocompatibility. (C) 2004 Wiley Periodicals, Inc.