The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects
The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects
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DOI：
10.1093/epirev/mxx007
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发表时间：
2017-01-01
影响因子：
5.5
通讯作者：
Schmitz, Kathryn H.
中科院分区：
文献类型：
--
作者：
Cormie, Prue;Zopf, Eva M.;Schmitz, Kathryn H.
新增癌症病例数量的增加和存活率的提高，导致了一个庞大而迅速增长的人口，他们有着独特的医疗保健需求。运动已被提出作为一种策略，以帮助解决癌症患者所面临的问题。在越来越多的研究的支持下，主要的健康组织通常认为将运动纳入癌症护理的重要性，并建议患者进行身体活动。这篇系统性综述全面总结了现有的流行病学和随机对照试验证据，调查运动在癌症管理中的作用。文献检索的重点是确定运动对1）癌症死亡率和复发的潜在影响，以及2）癌症及其治疗的不良反应。共审查了100项研究，涉及数千名患者，他们的运动行为在诊断出任何类型的癌症后进行了评估。与不运动/运动较少的患者相比，观察到诊断为癌症后运动的患者癌症死亡率和复发的相对风险较低，并且经历了较少/较不严重的不良反应。本综述的结果支持运动是癌症管理中重要的辅助治疗的观点。癌症护理政策和实践的影响进行了讨论。
The combination of an increasing number of new cancer cases and improving survival rates has led to a large and rapidly growing population with unique health-care requirements. Exercise has been proposed as a strategy to help address the issues faced by cancer patients. Supported by a growing body of research, major health organizations commonly identify the importance of incorporating exercise in cancer care and advise patients to be physically active. This systematic review comprehensively summarizes the available epidemiologic and randomized controlled trial evidence investigating the role of exercise in the management of cancer. Literature searches focused on determining the potential impact of exercise on 1) cancer mortality and recurrence and 2) adverse effects of cancer and its treatment. A total of 100 studies were reviewed involving thousands of individual patients whose exercise behavior was assessed following the diagnosis of any type of cancer. Compared with patients who performed no/less exercise, patients who exercised following a diagnosis of cancer were observed to have a lower relative risk of cancer mortality and recurrence and experienced fewer/less severe adverse effects. The findings of this review support the view that exercise is an important adjunct therapy in the management of cancer. Implications on cancer care policy and practice are discussed.