Breaking Symmetry - Asymmetric Histone Inheritance in Stem Cells.
Breaking Symmetry - Asymmetric Histone Inheritance in Stem Cells.
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DOI：
10.1016/j.tcb.2017.02.001
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发表时间：
2017-07
影响因子：
19
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Xie J;Wooten M;Tran V;Chen X
不对称细胞分裂（ACD）产生两个具有不同命运的子细胞。ACD在发育过程中被广泛使用，并且在组织稳态和再生过程中被许多类型的成体干细胞广泛使用。ACD可以由外在的线索，如信号分子，以及由内在因素，如细胞器和皮质蛋白调节。最近发现的不对称组蛋白遗传在干细胞ACD揭示了另一种内在机制，ACD产生两个不同的女儿。在这篇综述中，我们将讨论这些发现的背景下，细胞周期调控，以及其他研究的ACD，开始了解这种现象的潜在机制和生物相关性。
Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as organelles and cortex proteins. The recent discovery of asymmetric histone inheritance during stem cell ACD has revealed another intrinsic mechanism by which ACD produces two distinct daughters. In this review, we will discuss these findings in the context of cell cycle regulation, as well as other studies of ACD, to begin understanding the underlying mechanisms and biological relevance of this phenomenon.