Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies.
Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies.
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DOI：
10.1155/2017/5985209
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发表时间：
2017
影响因子：
--
通讯作者：
Zakynthinos E
中科院分区：
文献类型：
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作者：
Mantzarlis K;Tsolaki V;Zakynthinos E
脓毒症是重症监护病房最重要的死亡原因之一。尽管脓毒症的发病机制仍不清楚，但越来越多的证据表明氧化剂和抗氧化剂起着关键作用。上述物质的失衡有利于氧化剂被称为氧化应激，它有助于脓毒症的过程。最重要的后果是血管通透性受损、心脏功能下降和线粒体功能障碍导致呼吸受损。一氧化氮可能是最重要和研究最多的氧化剂。硒、维生素C和3 N-乙酰半胱氨酸等是恢复脓毒症氧化还原平衡的潜在疗法。最近的研究结果是有希望的，但需要在临床环境中进行更多的人体研究，以评估安全性和有效性。
Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant. Selenium, vitamin C, and 3N-acetylcysteine among others are potential therapies for the restoration of redox balance in sepsis. Results from recent studies are promising, but there is a need for more human studies in a clinical setting for safety and efficiency evaluation.