The Role of Axial Resolution of Optical Coherence Tomography on the Measurement of Corneal and Epithelial Thicknesses
The Role of Axial Resolution of Optical Coherence Tomography on the Measurement of Corneal and Epithelial Thicknesses
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DOI：
10.1167/iovs.11-9308
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发表时间：
2013-01-01
影响因子：
4.4
通讯作者：
Lu, Fan
中科院分区：
文献类型：
--
作者：
Ge, Lili;Yuan, Yimin;Lu, Fan
目的.我们的目的是研究光学相干断层扫描（OCT）的轴向分辨率对角膜和上皮厚度测量的作用，通过评估不同OCT设备之间具有不同轴向分辨率的重复性和一致性。对20名健康受试者的20只右眼（年龄：22.3 ± 1.3岁）和18名患者的18只右眼（年龄：25.7 ± 6.8岁）进行了激光原位角膜磨镶术（LASIK）屈光手术后的测试。每例受试者使用四种OCT设备进行成像：超高分辨率OCT（UHR-OCT）、超长扫描深度OCT（UL-OCT）、商业RTVue和Visante。使用自定义自动算法处理从UHR-OCT、UL-OCT和RTVue获得的OCT图像，以测量中央角膜厚度（CCT）和中央上皮厚度（ET）。还获得了由RTVue和Visante生成的厚度测量图的CCT测量值。对于两组，当使用自动图像处理算法时，UHR-OCT和UL-OCT测量的CCT和ET与RTVue高度相关。RTVue和Visante角膜厚度测量法的CCT测量值比自动算法获得的测量值厚。重复性系数小于4.9 μ m的健康受试者和7.9 μ m的LASIK患者，相关的组内相关系数（ICC）大于0.992，在两组的CCT测量。对于使用UHR-OCT、UL-OCT和RTVue的ET测量，在健康受试者中的重复性系数小于2.2 μ m，在ICC大于0.84的LASIK患者中的重复性系数为4.8 μ m。OCT的轴向分辨率可能在确定CCT和ET测量精度方面发挥作用，但可能不会影响结果的测量。（Invest Ophthalmol维斯科学。2013; 54：746-755）DOI：10.1167/iovs.11-9308
PURPOSE. Our purpose was to investigate the role of the axial resolution of optical coherence tomography (OCT) on the measurement of corneal and epithelial thickness by evaluating the repeatability and agreement among different OCT devices with different axial resolutions.METHODS. Twenty right eyes of 20 healthy subjects (age: 22.3 +/- 1.3 years) and 18 eyes of 18 patients (age: 25.7 +/- 6.8 years) after laser in situ keratomileusis (LASIK) refractive surgery were tested. Each subject was imaged using four OCT devices: ultra-high resolution OCT (UHR-OCT), ultra-long scan depth OCT (UL-OCT), commercial RTVue, and Visante. The OCT images obtained from UHR-OCT, UL-OCT, and RTVue were processed with a custom automated algorithm for measuring the central corneal thickness (CCT) and central epithelial thickness (ET). CCT measurements from pachymetry maps that were generated by RTVue and Visante were also obtained.RESULTS. For both groups, the CCT and ET measured by UHR-OCT and UL-OCT were highly correlated with RTVue when the automated image processing algorithm was used. The CCT measurements from the RTVue and Visante pachymetry were thicker than those measurements obtained from the automatic algorithm. The coefficient of repeatability was less than 4.9 mu m in the healthy subjects and 7.9 mu m in the LASIK patients, and the associated intraclass correlation coefficient (ICC) was greater than 0.992 in both groups for the CCT measurements. For the ET measurements using UHR-OCT, UL-OCT and RTVue, the coefficient of repeatability was less than 2.2 mu m in the healthy subjects and 4.8 mu m in the LASIK patients with an ICC that was greater than 0.84.CONCLUSIONS. The axial resolution of OCT may play a role in determining the precision with which the CCT and the ET can be measured, although it may not affect the measurement of results. (Invest Ophthalmol Vis Sci. 2013; 54: 746-755) DOI:10.1167/iovs.11-9308