Rickettsia felis: A Review of Transmission Mechanisms of an Emerging Pathogen.
Rickettsia felis: A Review of Transmission Mechanisms of an Emerging Pathogen.
复制标题
DOI：
10.3390/tropicalmed2040064
复制
发表时间：
2017-12-19
影响因子：
2.9
通讯作者：
Macaluso KR
中科院分区：
文献类型：
--
作者：
Legendre KP;Macaluso KR
猫立克次体是立克次体过渡群的一种新病原体，是非洲发热性疾病的重要病因。自20世纪90年代初首次发现该生物以来，许多研究都致力于阐明主要宿主和宿主猫蚤（Ctenocephalides felis）内的传播机制。已经详细描述了该媒介内垂直和水平传播的几种机制，以及向其他节肢动物媒介的传播，包括其他种类的跳蚤。然而，虽然越来越多的人类蚤传斑疹热病例在世界各地被报道，但尚未发现从节肢动物宿主到脊椎动物宿主导致疾病的明确传播机制。目前正在研究几种可能的机制，包括受感染节肢动物的叮咬和与传染性节肢动物粪便的关系。
Rickettsia felis is an emerging pathogen of the transitional group of Rickettsia species and an important cause of febrile illness in Africa. Since the organism’s original discovery in the early 1990s, much research has been directed towards elucidating transmission mechanisms within the primary host and reservoir, the cat flea (Ctenocephalides felis). Several mechanisms for vertical and horizontal transmission within this vector have been thoroughly described, as well as transmission to other arthropod vectors, including other species of fleas. However, while a growing number of human cases of flea-borne spotted fever are being reported throughout the world, a definitive transmission mechanism from arthropod host to vertebrate host resulting in disease has not been found. Several possible mechanisms, including bite of infected arthropods and association with infectious arthropod feces, are currently being investigated.